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Encephalitis lethargica: lessons for contemporary neuropsychiatry.
J Neuropsychiatry Clin Neurosci. 1995 Spring; 7(2):125-34.JN

Abstract

Encephalitis lethargica (von Economo's encephalitis), pandemic from 1917 to 1926, opened a window on the study of behavioral consequences of infection-induced subcortical disorder. Widely varying acute manifestations included extrapyramidal disorders, myoclonus, eye movement disorders, paralyses, delirium, mood changes, inverted diurnal rhythms, and catatonia. Major pathological changes involved the substantia nigra, globus pallidus, and hypothalamus. A symptom-free recovery period was often followed by postencephalitic disturbances, typically parkinsonism in adults and conduct disorder in children. Occurrence of depression, mania, obsessive-compulsive disorder, and hyperactivity in post-encephalitic patients anticipated current concepts of the role of the basal ganglia in mood, personality, and obsessional syndromes. Observations of deferred onset and "tardy" hyperkinesias presaged current theories of the pathophysiology of tardive dyskinesia.

Authors+Show Affiliations

Department of Neurology, UCLA School of Medicine 90024, USA.No affiliation info available

Pub Type(s)

Biography
Historical Article
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

7626955

Citation

Cheyette, S R., and J L. Cummings. "Encephalitis Lethargica: Lessons for Contemporary Neuropsychiatry." The Journal of Neuropsychiatry and Clinical Neurosciences, vol. 7, no. 2, 1995, pp. 125-34.
Cheyette SR, Cummings JL. Encephalitis lethargica: lessons for contemporary neuropsychiatry. J Neuropsychiatry Clin Neurosci. 1995;7(2):125-34.
Cheyette, S. R., & Cummings, J. L. (1995). Encephalitis lethargica: lessons for contemporary neuropsychiatry. The Journal of Neuropsychiatry and Clinical Neurosciences, 7(2), 125-34.
Cheyette SR, Cummings JL. Encephalitis Lethargica: Lessons for Contemporary Neuropsychiatry. J Neuropsychiatry Clin Neurosci. 1995;7(2):125-34. PubMed PMID: 7626955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Encephalitis lethargica: lessons for contemporary neuropsychiatry. AU - Cheyette,S R, AU - Cummings,J L, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 125 EP - 34 JF - The Journal of neuropsychiatry and clinical neurosciences JO - J Neuropsychiatry Clin Neurosci VL - 7 IS - 2 N2 - Encephalitis lethargica (von Economo's encephalitis), pandemic from 1917 to 1926, opened a window on the study of behavioral consequences of infection-induced subcortical disorder. Widely varying acute manifestations included extrapyramidal disorders, myoclonus, eye movement disorders, paralyses, delirium, mood changes, inverted diurnal rhythms, and catatonia. Major pathological changes involved the substantia nigra, globus pallidus, and hypothalamus. A symptom-free recovery period was often followed by postencephalitic disturbances, typically parkinsonism in adults and conduct disorder in children. Occurrence of depression, mania, obsessive-compulsive disorder, and hyperactivity in post-encephalitic patients anticipated current concepts of the role of the basal ganglia in mood, personality, and obsessional syndromes. Observations of deferred onset and "tardy" hyperkinesias presaged current theories of the pathophysiology of tardive dyskinesia. SN - 0895-0172 UR - https://www.unboundmedicine.com/medline/citation/7626955/full_citation L2 - https://neuro.psychiatryonline.org/doi/10.1176/jnp.7.2.125?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -