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Highly increased insulin secretion in a patient with postprandial hypoglycemia: role of glucagon-like peptide-1 (7-36) amide.
Endocr J. 1995 Apr; 42(2):147-51.EJ

Abstract

The mechanism(s) of an inappropriate secretion of insulin is poorly understood. We report a case of reactive hypoglycemia associated with an unusually exaggerated insulin secretion. The patient, a 32-year-old man, developed frequent episodes of postprandial hypoglycemia after interferon treatment was begun for chronic type C hepatitis. Oral glucose challenge test confirmed the patient's extremely high plasma IRI response, i.e., more than 1000 microU/ml, and that of plasma C-peptide 56.9 ng/ml at 90 min, followed by symptomatic hypoglycemia (plasma glucose 34 mg/dl) at 240 min. The plasma proinsulin level also was high, but the molar ratio of immuno reactive insulin (IRI)/plasma C-peptide and IRI/proinsulin was within the normal range. Antibodies to insulin or insulin-receptor were negative. Plasma IRI response was apparently greater when the glucose was given orally than when given intravenously. The response of plasma glucagon-like-peptide (GLP)-1 to oral glucose was quite high (from baseline of 45.5 to 303.2 pmol/L) and showed a close parallel with the change in the plasma IRI concentration. The greatly enhanced insulin secretion leading to reactive hypoglycemia in this patient may therefore be attributed to the increased secretion of GLP-1.

Authors+Show Affiliations

Diabetes Center, Tokyo Women's Medical College, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7627258

Citation

Owada, K, et al. "Highly Increased Insulin Secretion in a Patient With Postprandial Hypoglycemia: Role of Glucagon-like Peptide-1 (7-36) Amide." Endocrine Journal, vol. 42, no. 2, 1995, pp. 147-51.
Owada K, Wasada T, Miyazono Y, et al. Highly increased insulin secretion in a patient with postprandial hypoglycemia: role of glucagon-like peptide-1 (7-36) amide. Endocr J. 1995;42(2):147-51.
Owada, K., Wasada, T., Miyazono, Y., Yoshino, H., Hasumi, S., Kuroki, H., Yano, K., Maruyama, A., Kawai, K., & Omori, Y. (1995). Highly increased insulin secretion in a patient with postprandial hypoglycemia: role of glucagon-like peptide-1 (7-36) amide. Endocrine Journal, 42(2), 147-51.
Owada K, et al. Highly Increased Insulin Secretion in a Patient With Postprandial Hypoglycemia: Role of Glucagon-like Peptide-1 (7-36) Amide. Endocr J. 1995;42(2):147-51. PubMed PMID: 7627258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly increased insulin secretion in a patient with postprandial hypoglycemia: role of glucagon-like peptide-1 (7-36) amide. AU - Owada,K, AU - Wasada,T, AU - Miyazono,Y, AU - Yoshino,H, AU - Hasumi,S, AU - Kuroki,H, AU - Yano,K, AU - Maruyama,A, AU - Kawai,K, AU - Omori,Y, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 147 EP - 51 JF - Endocrine journal JO - Endocr J VL - 42 IS - 2 N2 - The mechanism(s) of an inappropriate secretion of insulin is poorly understood. We report a case of reactive hypoglycemia associated with an unusually exaggerated insulin secretion. The patient, a 32-year-old man, developed frequent episodes of postprandial hypoglycemia after interferon treatment was begun for chronic type C hepatitis. Oral glucose challenge test confirmed the patient's extremely high plasma IRI response, i.e., more than 1000 microU/ml, and that of plasma C-peptide 56.9 ng/ml at 90 min, followed by symptomatic hypoglycemia (plasma glucose 34 mg/dl) at 240 min. The plasma proinsulin level also was high, but the molar ratio of immuno reactive insulin (IRI)/plasma C-peptide and IRI/proinsulin was within the normal range. Antibodies to insulin or insulin-receptor were negative. Plasma IRI response was apparently greater when the glucose was given orally than when given intravenously. The response of plasma glucagon-like-peptide (GLP)-1 to oral glucose was quite high (from baseline of 45.5 to 303.2 pmol/L) and showed a close parallel with the change in the plasma IRI concentration. The greatly enhanced insulin secretion leading to reactive hypoglycemia in this patient may therefore be attributed to the increased secretion of GLP-1. SN - 0918-8959 UR - https://www.unboundmedicine.com/medline/citation/7627258/Highly_increased_insulin_secretion_in_a_patient_with_postprandial_hypoglycemia:_role_of_glucagon_like_peptide_1__7_36__amide_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/endocrj1993/42.147?from=PubMed DB - PRIME DP - Unbound Medicine ER -