Tags

Type your tag names separated by a space and hit enter

[Study of type I and IV collagenase activity in human thyroid diseases].
Nihon Jibiinkoka Gakkai Kaiho. 1995 Jun; 98(6):937-41.NJ

Abstract

The activity of type I and IV collagenase was measured in thyroid tissue obtained from 6 non-diseased thyroids, 4 patients with Graves' diseases, 5 with follicular adenoma, 6 with papillary carcinoma and 4 with follicular carcinomas. The relationship between these enzyme activities and invasion or metastasis of the original tumors was studied. The activity of type I collagenase in papillary carcinomas and follicular carcinomas was higher than in non-diseased thyroids, Graves' disease and follicular adenoma. Carcinoma tissue with invasion beyond the capsule in particular had higher type I collagenase activity. Type IV collagenase activity in carcinoma with lymph node metastasis was higher than in non-diseased thyroids, Graves' disease and follicular adenoma, and especially higher than carcinoma without lymph node metastasis. These findings suggest that increased type I collagenase activity plays an important role in local invasion in thyroid carcinoma, and that increased type IV collagenase activity plays an important role in lymph node metastasis.

Authors+Show Affiliations

Department of Otolaryngology, Kinki University School of Medicine, Osaka.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

7629646

Citation

Nakano, T, et al. "[Study of Type I and IV Collagenase Activity in Human Thyroid Diseases]." Nihon Jibiinkoka Gakkai Kaiho, vol. 98, no. 6, 1995, pp. 937-41.
Nakano T, Kusunoki T, Funasaka K, et al. [Study of type I and IV collagenase activity in human thyroid diseases]. Nihon Jibiinkoka Gakkai Kaiho. 1995;98(6):937-41.
Nakano, T., Kusunoki, T., Funasaka, K., Murata, K., Nishida, S., & tomura, T. (1995). [Study of type I and IV collagenase activity in human thyroid diseases]. Nihon Jibiinkoka Gakkai Kaiho, 98(6), 937-41.
Nakano T, et al. [Study of Type I and IV Collagenase Activity in Human Thyroid Diseases]. Nihon Jibiinkoka Gakkai Kaiho. 1995;98(6):937-41. PubMed PMID: 7629646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of type I and IV collagenase activity in human thyroid diseases]. AU - Nakano,T, AU - Kusunoki,T, AU - Funasaka,K, AU - Murata,K, AU - Nishida,S, AU - tomura,T, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 937 EP - 41 JF - Nihon Jibiinkoka Gakkai kaiho JO - Nihon Jibiinkoka Gakkai Kaiho VL - 98 IS - 6 N2 - The activity of type I and IV collagenase was measured in thyroid tissue obtained from 6 non-diseased thyroids, 4 patients with Graves' diseases, 5 with follicular adenoma, 6 with papillary carcinoma and 4 with follicular carcinomas. The relationship between these enzyme activities and invasion or metastasis of the original tumors was studied. The activity of type I collagenase in papillary carcinomas and follicular carcinomas was higher than in non-diseased thyroids, Graves' disease and follicular adenoma. Carcinoma tissue with invasion beyond the capsule in particular had higher type I collagenase activity. Type IV collagenase activity in carcinoma with lymph node metastasis was higher than in non-diseased thyroids, Graves' disease and follicular adenoma, and especially higher than carcinoma without lymph node metastasis. These findings suggest that increased type I collagenase activity plays an important role in local invasion in thyroid carcinoma, and that increased type IV collagenase activity plays an important role in lymph node metastasis. SN - 0030-6622 UR - https://www.unboundmedicine.com/medline/citation/7629646/[Study_of_type_I_and_IV_collagenase_activity_in_human_thyroid_diseases]_ L2 - http://www.medicalonline.jp/meteo_linkout.php?issn=0030-6622&volume=98&issue=6&spage=937 DB - PRIME DP - Unbound Medicine ER -