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Benzo[a]pyrene-induced alterations in total immune cell number and cell-surface antigen expression in the thymus, spleen and bone marrow of B6C3F1 mice.
Vet Hum Toxicol. 1995 Apr; 37(2):99-104.VH

Abstract

Although considerable evidence suggests that carcinogenic polycyclic aromatic hydrocarbons are immunosuppressive compounds, limited information is available regarding precise effects of these agents on immune cells. In the present report, the effect of subchronic exposure to benzo[a]pyrene (B[a]P) on immune cells in bone marrow, thymus and spleen of B6C3F1 mice was investigated. B[a]P treatment was found to reduce thymic cellularity and also to significantly alter normal thymocyte differentiation, as indicated by expression of CD4 and CD8 cell-surface antigens. Exposure to B[a]P also reduced cellularity of the bone marrow, including decreased percentage and absolute number of CD45R+ B-lineage lymphocytes. Further, B[a]P treatment dramatically increased the percentage of CD44hi cells in bone marrow, while proportionately reducing CD44lo cells. These results may indicate CD44lo bone marrow cells, including prolymphocytic cells, represent sensitive targets of B[a]P. The spleens of treated mice were found deficient in both Thy 1.2+ T lymphocytes and CD45R+ B lymphocytes, effects that correlate well with the chemical-induced alterations observed in thymus and bone marrow, respectively.

Authors+Show Affiliations

Department of Biomedical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061-0442, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7631501

Citation

Holladay, S D., and B J. Smith. "Benzo[a]pyrene-induced Alterations in Total Immune Cell Number and Cell-surface Antigen Expression in the Thymus, Spleen and Bone Marrow of B6C3F1 Mice." Veterinary and Human Toxicology, vol. 37, no. 2, 1995, pp. 99-104.
Holladay SD, Smith BJ. Benzo[a]pyrene-induced alterations in total immune cell number and cell-surface antigen expression in the thymus, spleen and bone marrow of B6C3F1 mice. Vet Hum Toxicol. 1995;37(2):99-104.
Holladay, S. D., & Smith, B. J. (1995). Benzo[a]pyrene-induced alterations in total immune cell number and cell-surface antigen expression in the thymus, spleen and bone marrow of B6C3F1 mice. Veterinary and Human Toxicology, 37(2), 99-104.
Holladay SD, Smith BJ. Benzo[a]pyrene-induced Alterations in Total Immune Cell Number and Cell-surface Antigen Expression in the Thymus, Spleen and Bone Marrow of B6C3F1 Mice. Vet Hum Toxicol. 1995;37(2):99-104. PubMed PMID: 7631501.
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TY - JOUR T1 - Benzo[a]pyrene-induced alterations in total immune cell number and cell-surface antigen expression in the thymus, spleen and bone marrow of B6C3F1 mice. AU - Holladay,S D, AU - Smith,B J, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 99 EP - 104 JF - Veterinary and human toxicology JO - Vet Hum Toxicol VL - 37 IS - 2 N2 - Although considerable evidence suggests that carcinogenic polycyclic aromatic hydrocarbons are immunosuppressive compounds, limited information is available regarding precise effects of these agents on immune cells. In the present report, the effect of subchronic exposure to benzo[a]pyrene (B[a]P) on immune cells in bone marrow, thymus and spleen of B6C3F1 mice was investigated. B[a]P treatment was found to reduce thymic cellularity and also to significantly alter normal thymocyte differentiation, as indicated by expression of CD4 and CD8 cell-surface antigens. Exposure to B[a]P also reduced cellularity of the bone marrow, including decreased percentage and absolute number of CD45R+ B-lineage lymphocytes. Further, B[a]P treatment dramatically increased the percentage of CD44hi cells in bone marrow, while proportionately reducing CD44lo cells. These results may indicate CD44lo bone marrow cells, including prolymphocytic cells, represent sensitive targets of B[a]P. The spleens of treated mice were found deficient in both Thy 1.2+ T lymphocytes and CD45R+ B lymphocytes, effects that correlate well with the chemical-induced alterations observed in thymus and bone marrow, respectively. SN - 0145-6296 UR - https://www.unboundmedicine.com/medline/citation/7631501/Benzo[a]pyrene_induced_alterations_in_total_immune_cell_number_and_cell_surface_antigen_expression_in_the_thymus_spleen_and_bone_marrow_of_B6C3F1_mice_ L2 - https://medlineplus.gov/stemcells.html DB - PRIME DP - Unbound Medicine ER -