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Effects of PEEP on liver arterial and venous blood flows.
Am J Respir Crit Care Med. 1995 Aug; 152(2):504-10.AJ

Abstract

Total venous return decreases with positive end-expiratory pressure (PEEP). It is likely that the liver plays an important role in this response, either through the development of an increase in venous resistance or through an increase in the venous backpressure at the outflow end of the liver. In addition, hepatic arterial flow is reported to be selectively decreased by the application of PEEP. Therefore, to clarify the effects of PEEP on liver hemodynamics, we generated pressure-flow (P-Q) relationships in both liver vascular beds of anesthetized, mechanically ventilated pigs at PEEP of 0, 5, 10, and 15 cm H2O to obtain values of backpressure (Pback, mm Hg) from linear extrapolation of the P-Q relationships and resistance (mm Hg/ml/min/kg) from its slope. PEEP decreased portal vein flow (Qpv) and caused an increase in the liver venous resistance (from 0.08 +/- 0.01 to 0.16 +/- 0.02 mm Hg/ml/min/kg; p < 0.05). Ppvback and right atrial pressure (Pra) increased equally (from 5.1 +/- 0.3 to 9.9 +/- 0.4 mm Hg, p < 0.05, and from 4.0 +/- 0.2 to 8.6 +/- 0.5 mm Hg, p < 0.05, respectively, at PEEP 15). The reduction in portal venous flow was related to an increase in the backpressure to flow (as a result of an increase in Pra) and to an increase in liver venous resistances that may cause blood pooling in the splanchnic compartment and decrease venous return through the liver. PEEP increased Phaback (from 11.2 +/- 0.9 to 14.5 +/- 0.7 mm Hg at PEEP 15, p < 0.05) but did not change hepatic arterial resistance.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Anesthesia and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7633699

Citation

Brienza, N, et al. "Effects of PEEP On Liver Arterial and Venous Blood Flows." American Journal of Respiratory and Critical Care Medicine, vol. 152, no. 2, 1995, pp. 504-10.
Brienza N, Revelly JP, Ayuse T, et al. Effects of PEEP on liver arterial and venous blood flows. Am J Respir Crit Care Med. 1995;152(2):504-10.
Brienza, N., Revelly, J. P., Ayuse, T., & Robotham, J. L. (1995). Effects of PEEP on liver arterial and venous blood flows. American Journal of Respiratory and Critical Care Medicine, 152(2), 504-10.
Brienza N, et al. Effects of PEEP On Liver Arterial and Venous Blood Flows. Am J Respir Crit Care Med. 1995;152(2):504-10. PubMed PMID: 7633699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of PEEP on liver arterial and venous blood flows. AU - Brienza,N, AU - Revelly,J P, AU - Ayuse,T, AU - Robotham,J L, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 504 EP - 10 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 152 IS - 2 N2 - Total venous return decreases with positive end-expiratory pressure (PEEP). It is likely that the liver plays an important role in this response, either through the development of an increase in venous resistance or through an increase in the venous backpressure at the outflow end of the liver. In addition, hepatic arterial flow is reported to be selectively decreased by the application of PEEP. Therefore, to clarify the effects of PEEP on liver hemodynamics, we generated pressure-flow (P-Q) relationships in both liver vascular beds of anesthetized, mechanically ventilated pigs at PEEP of 0, 5, 10, and 15 cm H2O to obtain values of backpressure (Pback, mm Hg) from linear extrapolation of the P-Q relationships and resistance (mm Hg/ml/min/kg) from its slope. PEEP decreased portal vein flow (Qpv) and caused an increase in the liver venous resistance (from 0.08 +/- 0.01 to 0.16 +/- 0.02 mm Hg/ml/min/kg; p < 0.05). Ppvback and right atrial pressure (Pra) increased equally (from 5.1 +/- 0.3 to 9.9 +/- 0.4 mm Hg, p < 0.05, and from 4.0 +/- 0.2 to 8.6 +/- 0.5 mm Hg, p < 0.05, respectively, at PEEP 15). The reduction in portal venous flow was related to an increase in the backpressure to flow (as a result of an increase in Pra) and to an increase in liver venous resistances that may cause blood pooling in the splanchnic compartment and decrease venous return through the liver. PEEP increased Phaback (from 11.2 +/- 0.9 to 14.5 +/- 0.7 mm Hg at PEEP 15, p < 0.05) but did not change hepatic arterial resistance.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/7633699/Effects_of_PEEP_on_liver_arterial_and_venous_blood_flows_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm.152.2.7633699?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -