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Hypercalcemia and bone resorption in malignancy.
Clin Orthop Relat Res. 1995 MarCO

Abstract

Hypercalcemia is the most common paraneoplastic syndrome associated with cancer. This paper addresses the etiology and pathogenesis of hypercalcemia of malignancy and discusses the relative contributions of local and humoral effects on bone and renal calcium homeostasis. The roles of parathyroid hormone-related protein and other osteolytic cytokines are outlined. New biochemical markers that enable more specific monitoring of the response of bone metastases to treatment are introduced, including urinary excretion of the collagen crosslinks pyridinoline and deoxypyridinoline. The clinical management and prevention of hypercalcemia is systemically outlined, including indications for bisphosphonate, glucocorticoid, and calcitonin therapy. The results of recent trials of bisphosphonate therapy for the prevention of tumor progression and its subsequent problems such as bone pain, fracture, and hypercalcemia also are discussed.

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Authors+Show Affiliations

Walls J
Department of Surgery, Northern General Hospital, Sheffield, England.
Bundred N
No affiliation info available
Howell A
No affiliation info available

MeSH

AnimalsBone NeoplasmsBreast NeoplasmsCytokinesDiphosphonatesDisease ProgressionHumansHypercalcemiaOsteolysisParaneoplastic Syndromes

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

7634618

Citation

Walls, J, et al. "Hypercalcemia and Bone Resorption in Malignancy." Clinical Orthopaedics and Related Research, 1995, pp. 51-63.
Walls J, Bundred N, Howell A. Hypercalcemia and bone resorption in malignancy. Clin Orthop Relat Res. 1995.
Walls, J., Bundred, N., & Howell, A. (1995). Hypercalcemia and bone resorption in malignancy. Clinical Orthopaedics and Related Research, (312), 51-63.
Walls J, Bundred N, Howell A. Hypercalcemia and Bone Resorption in Malignancy. Clin Orthop Relat Res. 1995;(312)51-63. PubMed PMID: 7634618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypercalcemia and bone resorption in malignancy. AU - Walls,J, AU - Bundred,N, AU - Howell,A, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 51 EP - 63 JF - Clinical orthopaedics and related research JO - Clin Orthop Relat Res IS - 312 N2 - Hypercalcemia is the most common paraneoplastic syndrome associated with cancer. This paper addresses the etiology and pathogenesis of hypercalcemia of malignancy and discusses the relative contributions of local and humoral effects on bone and renal calcium homeostasis. The roles of parathyroid hormone-related protein and other osteolytic cytokines are outlined. New biochemical markers that enable more specific monitoring of the response of bone metastases to treatment are introduced, including urinary excretion of the collagen crosslinks pyridinoline and deoxypyridinoline. The clinical management and prevention of hypercalcemia is systemically outlined, including indications for bisphosphonate, glucocorticoid, and calcitonin therapy. The results of recent trials of bisphosphonate therapy for the prevention of tumor progression and its subsequent problems such as bone pain, fracture, and hypercalcemia also are discussed. SN - 0009-921X UR - https://www.unboundmedicine.com/medline/citation/7634618/Hypercalcemia_and_bone_resorption_in_malignancy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7634618.ui DB - PRIME DP - Unbound Medicine ER -