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From free radicals to electronically excited species.
Free Radic Biol Med 1995; 19(1):103-14FR

Abstract

Biologically/medically important compounds, when metabolized, can generate free radicals from which electrically excited products--often in the triplet state--are generated. Peroxidases are particularly apt to catalyze such processes, which usually entail oxidations by electron transfer. In the latter case, the chemiluminescence may derive from peroxyl and alkoxyl radicals or excited states derived from dioxetanes. Besides peroxidases, prostaglandin-H synthase and lipoxygenase may catalyze the formation of excited carbonyls. The pronounced similarity in the chemical behavior and reactivity of radicals and excited species derives in part from the biradical nature of the latter. Usually in analyzing the biological effects of xenobiotics, only radicals and/or reactive ground state products have been considered. However, in such processes the generation of excited species is possible, which should be tested for by direct and/or sensitized emission or by photochemical transformation.

Authors+Show Affiliations

Department of Biochemistry, Universidade de São Paulo, Brazil.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

7635351

Citation

Cilento, G, and W Adam. "From Free Radicals to Electronically Excited Species." Free Radical Biology & Medicine, vol. 19, no. 1, 1995, pp. 103-14.
Cilento G, Adam W. From free radicals to electronically excited species. Free Radic Biol Med. 1995;19(1):103-14.
Cilento, G., & Adam, W. (1995). From free radicals to electronically excited species. Free Radical Biology & Medicine, 19(1), pp. 103-14.
Cilento G, Adam W. From Free Radicals to Electronically Excited Species. Free Radic Biol Med. 1995;19(1):103-14. PubMed PMID: 7635351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From free radicals to electronically excited species. AU - Cilento,G, AU - Adam,W, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 103 EP - 14 JF - Free radical biology & medicine JO - Free Radic. Biol. Med. VL - 19 IS - 1 N2 - Biologically/medically important compounds, when metabolized, can generate free radicals from which electrically excited products--often in the triplet state--are generated. Peroxidases are particularly apt to catalyze such processes, which usually entail oxidations by electron transfer. In the latter case, the chemiluminescence may derive from peroxyl and alkoxyl radicals or excited states derived from dioxetanes. Besides peroxidases, prostaglandin-H synthase and lipoxygenase may catalyze the formation of excited carbonyls. The pronounced similarity in the chemical behavior and reactivity of radicals and excited species derives in part from the biradical nature of the latter. Usually in analyzing the biological effects of xenobiotics, only radicals and/or reactive ground state products have been considered. However, in such processes the generation of excited species is possible, which should be tested for by direct and/or sensitized emission or by photochemical transformation. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/7635351/From_free_radicals_to_electronically_excited_species_ L2 - https://linkinghub.elsevier.com/retrieve/pii/089158499500002F DB - PRIME DP - Unbound Medicine ER -