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Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression.
J Clin Invest. 1995 Aug; 96(2):858-66.JCI

Abstract

Continued adverse remodeling of myocardium after infarction may lead to progressive ventricular dilation and heart failure. We tested the hypothesis that exercise training in a healed myocardial infarction-dysfunction rat model can favorably modify the adverse effects of ventricular remodeling including attenuation of abnormal myosin gene expression. Sprague-Dawley rats were subjected to either proximal LAD ligation or sham operation. At 5 wk after the operation, animals were randomly assigned to sedentary conditions or 6 wk of graduated swim training, creating four experimental groups: infarct sedentary (IS), infarct exercise (IE), sham sedentary (SS), and sham exercise (SE). At 11 wk all rats were sacrificed and analyzed. Compared to sedentary infarct controls, exercise training attenuated left ventricular (LV) dilation and allowed more hypertrophy of the non infarct wall. The exercise-trained hearts also showed a reduction in the estimated peak wall tension. Northern blot analysis showed an increase in beta-myosin heavy chain expression in the hearts of the sedentary infarction group soon after infarction when compared to sham controls. However, with exercise training, there was a significant attenuation of the beta-myosin heavy chain expression in the myocardium. Exercise training in a model of left ventricular dysfunction after healed myocardial infarction can improve the adverse remodeling process by attenuating ventricular dilation and reducing wall tension. The abnormal beta-myosin expression was also attenuated in the exercise trained group. This is evidence that abnormal gene expression following severe myocardial infarction dysfunction can be favorably modified by an intervention.

Authors+Show Affiliations

Center for Cardiovascular Research, Toronto Hospital, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7635980

Citation

Orenstein, T L., et al. "Favorable Left Ventricular Remodeling Following Large Myocardial Infarction By Exercise Training. Effect On Ventricular Morphology and Gene Expression." The Journal of Clinical Investigation, vol. 96, no. 2, 1995, pp. 858-66.
Orenstein TL, Parker TG, Butany JW, et al. Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression. J Clin Invest. 1995;96(2):858-66.
Orenstein, T. L., Parker, T. G., Butany, J. W., Goodman, J. M., Dawood, F., Wen, W. H., Wee, L., Martino, T., McLaughlin, P. R., & Liu, P. P. (1995). Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression. The Journal of Clinical Investigation, 96(2), 858-66.
Orenstein TL, et al. Favorable Left Ventricular Remodeling Following Large Myocardial Infarction By Exercise Training. Effect On Ventricular Morphology and Gene Expression. J Clin Invest. 1995;96(2):858-66. PubMed PMID: 7635980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression. AU - Orenstein,T L, AU - Parker,T G, AU - Butany,J W, AU - Goodman,J M, AU - Dawood,F, AU - Wen,W H, AU - Wee,L, AU - Martino,T, AU - McLaughlin,P R, AU - Liu,P P, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 858 EP - 66 JF - The Journal of clinical investigation JO - J Clin Invest VL - 96 IS - 2 N2 - Continued adverse remodeling of myocardium after infarction may lead to progressive ventricular dilation and heart failure. We tested the hypothesis that exercise training in a healed myocardial infarction-dysfunction rat model can favorably modify the adverse effects of ventricular remodeling including attenuation of abnormal myosin gene expression. Sprague-Dawley rats were subjected to either proximal LAD ligation or sham operation. At 5 wk after the operation, animals were randomly assigned to sedentary conditions or 6 wk of graduated swim training, creating four experimental groups: infarct sedentary (IS), infarct exercise (IE), sham sedentary (SS), and sham exercise (SE). At 11 wk all rats were sacrificed and analyzed. Compared to sedentary infarct controls, exercise training attenuated left ventricular (LV) dilation and allowed more hypertrophy of the non infarct wall. The exercise-trained hearts also showed a reduction in the estimated peak wall tension. Northern blot analysis showed an increase in beta-myosin heavy chain expression in the hearts of the sedentary infarction group soon after infarction when compared to sham controls. However, with exercise training, there was a significant attenuation of the beta-myosin heavy chain expression in the myocardium. Exercise training in a model of left ventricular dysfunction after healed myocardial infarction can improve the adverse remodeling process by attenuating ventricular dilation and reducing wall tension. The abnormal beta-myosin expression was also attenuated in the exercise trained group. This is evidence that abnormal gene expression following severe myocardial infarction dysfunction can be favorably modified by an intervention. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/7635980/Favorable_left_ventricular_remodeling_following_large_myocardial_infarction_by_exercise_training__Effect_on_ventricular_morphology_and_gene_expression_ L2 - https://doi.org/10.1172/JCI118132 DB - PRIME DP - Unbound Medicine ER -