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Relationships of plasma and hepatic variables with rates of plasma low-density lipoprotein apolipoprotein B metabolism in baboons fed low- and high-fat diets.
Metabolism. 1995 Aug; 44(8):1058-66.M

Abstract

These studies were conducted to determine relationships of plasma low-density lipoprotein (LDL) cholesterol concentrations and hepatic mRNA levels for apolipoprotein (apo) B, LDL receptor, and hepatic hydroxymethyl glutaryl coenzyme A (HMG CoA) synthase with plasma LDL apo B production and catabolic rates in baboons maintained on a low-cholesterol, low-fat chow diet and on a high-cholesterol, high-fat (HCHF) diet. Twelve baboons with LDL cholesterol levels ranging from low to high on the HCHF diet but with similar high-density lipoprotein (HDL) cholesterol levels were selected from a colony of selectively bred pedigreed baboons. LDL apo B turnover and hepatic mRNA concentrations for apo B, LDL receptor, and HMG CoA synthase were measured on a chow diet and again on a HCHF diet fed for 14 weeks. LDL apo B fractional catabolic rates decreased and production rates increased on the HCHF diet. Hepatic mRNA concentrations for apo B were not affected by the HCHF diet. Hepatic LDL receptor and HMG CoA synthase mRNA concentrations decreased on the HCHF diet as compared with the chow diet. LDL apo B fractional catabolic rate was negatively correlated with plasma cholesterol, LDL cholesterol, LDL apo B, and LDL apo B production and positively correlated with hepatic LDL receptor and HMG CoA synthase mRNA concentrations and with plasma LDL triglyceride to cholesterol ratio on the chow diet but not on the HCHF diet. LDL apo B production was positively correlated with plasma cholesterol, LDL cholesterol, and LDL apo B on the HCHF diet and negatively correlated with LDL triglyceride to cholesterol ratio on both chow and HCHF diets.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7637648

Citation

Kushwaha, R S., et al. "Relationships of Plasma and Hepatic Variables With Rates of Plasma Low-density Lipoprotein Apolipoprotein B Metabolism in Baboons Fed Low- and High-fat Diets." Metabolism: Clinical and Experimental, vol. 44, no. 8, 1995, pp. 1058-66.
Kushwaha RS, Barrett PH, Reardon CA, et al. Relationships of plasma and hepatic variables with rates of plasma low-density lipoprotein apolipoprotein B metabolism in baboons fed low- and high-fat diets. Metab Clin Exp. 1995;44(8):1058-66.
Kushwaha, R. S., Barrett, P. H., Reardon, C. A., Lewis, D. S., Carey, K. D., Getz, G. S., & McGill, H. C. (1995). Relationships of plasma and hepatic variables with rates of plasma low-density lipoprotein apolipoprotein B metabolism in baboons fed low- and high-fat diets. Metabolism: Clinical and Experimental, 44(8), 1058-66.
Kushwaha RS, et al. Relationships of Plasma and Hepatic Variables With Rates of Plasma Low-density Lipoprotein Apolipoprotein B Metabolism in Baboons Fed Low- and High-fat Diets. Metab Clin Exp. 1995;44(8):1058-66. PubMed PMID: 7637648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships of plasma and hepatic variables with rates of plasma low-density lipoprotein apolipoprotein B metabolism in baboons fed low- and high-fat diets. AU - Kushwaha,R S, AU - Barrett,P H, AU - Reardon,C A, AU - Lewis,D S, AU - Carey,K D, AU - Getz,G S, AU - McGill,H C,Jr PY - 1995/8/1/pubmed PY - 2001/3/28/medline PY - 1995/8/1/entrez SP - 1058 EP - 66 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 44 IS - 8 N2 - These studies were conducted to determine relationships of plasma low-density lipoprotein (LDL) cholesterol concentrations and hepatic mRNA levels for apolipoprotein (apo) B, LDL receptor, and hepatic hydroxymethyl glutaryl coenzyme A (HMG CoA) synthase with plasma LDL apo B production and catabolic rates in baboons maintained on a low-cholesterol, low-fat chow diet and on a high-cholesterol, high-fat (HCHF) diet. Twelve baboons with LDL cholesterol levels ranging from low to high on the HCHF diet but with similar high-density lipoprotein (HDL) cholesterol levels were selected from a colony of selectively bred pedigreed baboons. LDL apo B turnover and hepatic mRNA concentrations for apo B, LDL receptor, and HMG CoA synthase were measured on a chow diet and again on a HCHF diet fed for 14 weeks. LDL apo B fractional catabolic rates decreased and production rates increased on the HCHF diet. Hepatic mRNA concentrations for apo B were not affected by the HCHF diet. Hepatic LDL receptor and HMG CoA synthase mRNA concentrations decreased on the HCHF diet as compared with the chow diet. LDL apo B fractional catabolic rate was negatively correlated with plasma cholesterol, LDL cholesterol, LDL apo B, and LDL apo B production and positively correlated with hepatic LDL receptor and HMG CoA synthase mRNA concentrations and with plasma LDL triglyceride to cholesterol ratio on the chow diet but not on the HCHF diet. LDL apo B production was positively correlated with plasma cholesterol, LDL cholesterol, and LDL apo B on the HCHF diet and negatively correlated with LDL triglyceride to cholesterol ratio on both chow and HCHF diets.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/7637648/Relationships_of_plasma_and_hepatic_variables_with_rates_of_plasma_low_density_lipoprotein_apolipoprotein_B_metabolism_in_baboons_fed_low__and_high_fat_diets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(95)90105-1 DB - PRIME DP - Unbound Medicine ER -