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Genetic polymorphism (Arg353-->Gln) in coagulation factor VII gene and factor VII levels (coagulant activity, antigen and binding ability to tissue factor) in 101 healthy Japanese.
Scand J Clin Lab Invest. 1995 May; 55(3):211-5.SJ

Abstract

We studied the frequency of the Msp I genotype (Gln353) for factor VII in 101 young healthy Japanese individuals, and the levels of factor VII-related procoagulant activity (FVII:c), antigen (FVII:ag) and binding ability to tissue factor (FVII-TF binding). The frequency of the allele coding for the factor VII Gln353 was 0.05 among this group. Individuals with genotype M1M1 had an FVII:c of 103.52 +/- 17.85% (mean +/- SD), FVII:ag of 102.50 +/- 18.42% (mean +/- SD) and FVII-TF binding of 101.03 +/- 22.22% (mean +/- SD). Triglyceride levels of subjects with the M1M1 genotype were 84.34 +/- 44.97 mg dl-1 (mean +/- SD). FVII:c (50%), FVII:ag (45%) and FVII-TF binding (36%) from an individual with the M2M2 type was the lowest, with a triglyceride value of 39 mg dl-1. On the other hand, individuals with the genotype M1M2 had an FVII:c of 75.57 +/- 9.61% (mean +/- SD), FVII:ag of 72.43 +/- 8.54% (mean +/- SD) and FVII-TF binding of 68.14 +/- 14.91% (mean +/- SD). FVII:c, FVII:ag and FVII-TF binding in individuals with the M1M2 and M2M2 genotypes were significantly lower than those in individuals with the M1M1 genotype.

Authors+Show Affiliations

Department of Medical Technology, School of Allied Medical Sciences, Shinshu University, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7638554

Citation

Takamiya, O. "Genetic Polymorphism (Arg353-->Gln) in Coagulation Factor VII Gene and Factor VII Levels (coagulant Activity, Antigen and Binding Ability to Tissue Factor) in 101 Healthy Japanese." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 55, no. 3, 1995, pp. 211-5.
Takamiya O. Genetic polymorphism (Arg353-->Gln) in coagulation factor VII gene and factor VII levels (coagulant activity, antigen and binding ability to tissue factor) in 101 healthy Japanese. Scand J Clin Lab Invest. 1995;55(3):211-5.
Takamiya, O. (1995). Genetic polymorphism (Arg353-->Gln) in coagulation factor VII gene and factor VII levels (coagulant activity, antigen and binding ability to tissue factor) in 101 healthy Japanese. Scandinavian Journal of Clinical and Laboratory Investigation, 55(3), 211-5.
Takamiya O. Genetic Polymorphism (Arg353-->Gln) in Coagulation Factor VII Gene and Factor VII Levels (coagulant Activity, Antigen and Binding Ability to Tissue Factor) in 101 Healthy Japanese. Scand J Clin Lab Invest. 1995;55(3):211-5. PubMed PMID: 7638554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic polymorphism (Arg353-->Gln) in coagulation factor VII gene and factor VII levels (coagulant activity, antigen and binding ability to tissue factor) in 101 healthy Japanese. A1 - Takamiya,O, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 211 EP - 5 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 55 IS - 3 N2 - We studied the frequency of the Msp I genotype (Gln353) for factor VII in 101 young healthy Japanese individuals, and the levels of factor VII-related procoagulant activity (FVII:c), antigen (FVII:ag) and binding ability to tissue factor (FVII-TF binding). The frequency of the allele coding for the factor VII Gln353 was 0.05 among this group. Individuals with genotype M1M1 had an FVII:c of 103.52 +/- 17.85% (mean +/- SD), FVII:ag of 102.50 +/- 18.42% (mean +/- SD) and FVII-TF binding of 101.03 +/- 22.22% (mean +/- SD). Triglyceride levels of subjects with the M1M1 genotype were 84.34 +/- 44.97 mg dl-1 (mean +/- SD). FVII:c (50%), FVII:ag (45%) and FVII-TF binding (36%) from an individual with the M2M2 type was the lowest, with a triglyceride value of 39 mg dl-1. On the other hand, individuals with the genotype M1M2 had an FVII:c of 75.57 +/- 9.61% (mean +/- SD), FVII:ag of 72.43 +/- 8.54% (mean +/- SD) and FVII-TF binding of 68.14 +/- 14.91% (mean +/- SD). FVII:c, FVII:ag and FVII-TF binding in individuals with the M1M2 and M2M2 genotypes were significantly lower than those in individuals with the M1M1 genotype. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/7638554/Genetic_polymorphism__Arg353__>Gln__in_coagulation_factor_VII_gene_and_factor_VII_levels__coagulant_activity_antigen_and_binding_ability_to_tissue_factor__in_101_healthy_Japanese_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365519509089615 DB - PRIME DP - Unbound Medicine ER -