Tags

Type your tag names separated by a space and hit enter

Lack of metabolic racemisation of ropivacaine, determined by liquid chromatography using a chiral AGP column.
Chirality. 1995; 7(4):272-7.C

Abstract

Ropivacaine hydrochloride monohydrate (ropivacaine) is a new local anaesthetic agent which is administered exclusively as the (-)-(S)-form. The aim of the study was to determine whether metabolic racemisation of (-)-(S)-ropivacaine occurs. This was tested in man, rat, dog, and sheep after different routes of administration. The enantiomers of ropivacaine and two of the major metabolites, 3-hydroxy-ropivacaine and 2',6'-pipecoloxylidide (PPX), were determined in urine samples by liquid chromatography on a Chiral AGP column after liquid-liquid extraction. It was possible to detect < 1% of the (+)-(R)-enantiomer of both ropivacaine and the two major metabolites. In the samples examined, no trace of metabolic racemisation was observed. In pharmacokinetic, pharmacodynamic, toxicological, and metabolic studies, therefore, nonchiral assays are considered to be adequate.

Authors+Show Affiliations

Department of Bioanalysis, Astra Pain Control AB, Södertälje, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7640170

Citation

Arvidsson, T, et al. "Lack of Metabolic Racemisation of Ropivacaine, Determined By Liquid Chromatography Using a Chiral AGP Column." Chirality, vol. 7, no. 4, 1995, pp. 272-7.
Arvidsson T, Bruce HF, Halldin MM. Lack of metabolic racemisation of ropivacaine, determined by liquid chromatography using a chiral AGP column. Chirality. 1995;7(4):272-7.
Arvidsson, T., Bruce, H. F., & Halldin, M. M. (1995). Lack of metabolic racemisation of ropivacaine, determined by liquid chromatography using a chiral AGP column. Chirality, 7(4), 272-7.
Arvidsson T, Bruce HF, Halldin MM. Lack of Metabolic Racemisation of Ropivacaine, Determined By Liquid Chromatography Using a Chiral AGP Column. Chirality. 1995;7(4):272-7. PubMed PMID: 7640170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of metabolic racemisation of ropivacaine, determined by liquid chromatography using a chiral AGP column. AU - Arvidsson,T, AU - Bruce,H F, AU - Halldin,M M, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 272 EP - 7 JF - Chirality JO - Chirality VL - 7 IS - 4 N2 - Ropivacaine hydrochloride monohydrate (ropivacaine) is a new local anaesthetic agent which is administered exclusively as the (-)-(S)-form. The aim of the study was to determine whether metabolic racemisation of (-)-(S)-ropivacaine occurs. This was tested in man, rat, dog, and sheep after different routes of administration. The enantiomers of ropivacaine and two of the major metabolites, 3-hydroxy-ropivacaine and 2',6'-pipecoloxylidide (PPX), were determined in urine samples by liquid chromatography on a Chiral AGP column after liquid-liquid extraction. It was possible to detect < 1% of the (+)-(R)-enantiomer of both ropivacaine and the two major metabolites. In the samples examined, no trace of metabolic racemisation was observed. In pharmacokinetic, pharmacodynamic, toxicological, and metabolic studies, therefore, nonchiral assays are considered to be adequate. SN - 0899-0042 UR - https://www.unboundmedicine.com/medline/citation/7640170/Lack_of_metabolic_racemisation_of_ropivacaine_determined_by_liquid_chromatography_using_a_chiral_AGP_column_ L2 - https://doi.org/10.1002/chir.530070414 DB - PRIME DP - Unbound Medicine ER -