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Neoadjuvant chemotherapy for the treatment of osteosarcoma of the extremities: excellent response of the primary tumor to preoperative treatment with methotrexate, cisplatin, adriamycin, and ifosfamide. Preliminary results.
Chir Organi Mov. 1995 Jan-Mar; 80(1):1-10.CO

Abstract

A total of 48 patients with non-metastatic osteosarcoma of the extremities were treated with a new neoadjuvant chemotherapy protocol which, prior to surgery, included the use of high dose methotrexate, cisplatin, adriamycin and ifosfamide. Cisplatin was administered intra-arterially, whereas the other drugs were given intravenously. In all of the cases response to this chemotherapy protocol was very good, allowing for conservative treatment in 46 out of 48 patients. Histological evaluation of chemotherapy response showed good (> 90%) and total necrosis in 87 and 54% of the cases, respectively. Drug toxicity was acceptable. Results were significantly better than those previously obtained in our and in other institutes when only three drugs were used (methotrexate, cisplatin, and adriamycin) in the preoperative treatment scheme. Since it has been demonstrated that grade of histological response to preoperative chemotherapy, and prognosis are closely related in osteosarcoma of the extremities treated with neoadjuvant chemotherapy, in addition to allowing for the use of conservative surgery in the majority of cases, this new protocol may also lead to a significant increase in the patient cure rate.

Authors+Show Affiliations

Sezione Chemioterapia dei Tumori dell'Apparato Locomotore, Istituti Ortopedici Rizzoli, Bologna.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study

Language

eng ita

PubMed ID

7641534

Citation

Bacci, G, et al. "Neoadjuvant Chemotherapy for the Treatment of Osteosarcoma of the Extremities: Excellent Response of the Primary Tumor to Preoperative Treatment With Methotrexate, Cisplatin, Adriamycin, and Ifosfamide. Preliminary Results." La Chirurgia Degli Organi Di Movimento, vol. 80, no. 1, 1995, pp. 1-10.
Bacci G, Picci P, Ferrari S, et al. Neoadjuvant chemotherapy for the treatment of osteosarcoma of the extremities: excellent response of the primary tumor to preoperative treatment with methotrexate, cisplatin, adriamycin, and ifosfamide. Preliminary results. Chir Organi Mov. 1995;80(1):1-10.
Bacci, G., Picci, P., Ferrari, S., Sangiorgi, L., Mercuri, M., Bertoni, F., Brach del Prever, A., Tienghi, A., Mancini, A., & Comandone, A. (1995). Neoadjuvant chemotherapy for the treatment of osteosarcoma of the extremities: excellent response of the primary tumor to preoperative treatment with methotrexate, cisplatin, adriamycin, and ifosfamide. Preliminary results. La Chirurgia Degli Organi Di Movimento, 80(1), 1-10.
Bacci G, et al. Neoadjuvant Chemotherapy for the Treatment of Osteosarcoma of the Extremities: Excellent Response of the Primary Tumor to Preoperative Treatment With Methotrexate, Cisplatin, Adriamycin, and Ifosfamide. Preliminary Results. Chir Organi Mov. 1995;80(1):1-10. PubMed PMID: 7641534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neoadjuvant chemotherapy for the treatment of osteosarcoma of the extremities: excellent response of the primary tumor to preoperative treatment with methotrexate, cisplatin, adriamycin, and ifosfamide. Preliminary results. A1 - Bacci,G, AU - Picci,P, AU - Ferrari,S, AU - Sangiorgi,L, AU - Mercuri,M, AU - Bertoni,F, AU - Brach del Prever,A, AU - Tienghi,A, AU - Mancini,A, AU - Comandone,A, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 1 EP - 10 JF - La Chirurgia degli organi di movimento JO - Chir Organi Mov VL - 80 IS - 1 N2 - A total of 48 patients with non-metastatic osteosarcoma of the extremities were treated with a new neoadjuvant chemotherapy protocol which, prior to surgery, included the use of high dose methotrexate, cisplatin, adriamycin and ifosfamide. Cisplatin was administered intra-arterially, whereas the other drugs were given intravenously. In all of the cases response to this chemotherapy protocol was very good, allowing for conservative treatment in 46 out of 48 patients. Histological evaluation of chemotherapy response showed good (> 90%) and total necrosis in 87 and 54% of the cases, respectively. Drug toxicity was acceptable. Results were significantly better than those previously obtained in our and in other institutes when only three drugs were used (methotrexate, cisplatin, and adriamycin) in the preoperative treatment scheme. Since it has been demonstrated that grade of histological response to preoperative chemotherapy, and prognosis are closely related in osteosarcoma of the extremities treated with neoadjuvant chemotherapy, in addition to allowing for the use of conservative surgery in the majority of cases, this new protocol may also lead to a significant increase in the patient cure rate. SN - 0009-4749 UR - https://www.unboundmedicine.com/medline/citation/7641534/Neoadjuvant_chemotherapy_for_the_treatment_of_osteosarcoma_of_the_extremities:_excellent_response_of_the_primary_tumor_to_preoperative_treatment_with_methotrexate_cisplatin_adriamycin_and_ifosfamide__Preliminary_results_ L2 - http://www.diseaseinfosearch.org/result/5489 DB - PRIME DP - Unbound Medicine ER -