Tags

Type your tag names separated by a space and hit enter

Breakdown of self-tolerance by intrathymic injection of a T-cell line inducing autoimmune gastritis in mice.
Immunology. 1995 Jun; 85(2):270-5.I

Abstract

Autoimmune gastritis (AIG) develops spontaneously in BALB/c mice thymectomized 3 days after birth (3d-Tx). We first confirmed our previous observations that CD4+ splenic T cells in AIG mice induced AIG in nu/nu mice, while those in normal mice suppressed the development of the disease. In addition, we found that a quantitative balance between these effector (Te) and suppressor (Ts) T cells determined either onset or prevention of the disease. Peripheralization of Ts seemed to begin around 3 days after birth, since the incidence of AIG in mice that underwent Tx 6 days after birth (6d-Tx) decreased markedly, compared with that of 3d-Tx mice; 12% in the former, while 79% in the latter. Notably, Ts existed in the 6d-Tx mice that escaped AIG. We next examined the target specificity of such Ts using syngeneic parietal cells known as autoantigens and two kinds of T-cell lines established from an AIG mouse; one is gastritis inducible in vivo, termed A-II, while another is not, named AC-II. Intrathymic injection of parietal cells into mice 3 days after birth followed by 6d-Tx completely prevented the development of AIG. In contrast, injection of irradiated A-II, but not AC-II cells resulted in AIG in 67% of the mice. No autoimmune oophoritis (AIO) was induced in female mice, implying that the breakdown of tolerance is organ specific. Taken together, peripheral tolerance for organ-specific autoantigens seems to be maintained by CD4+ Ts responding to Te, which induces the disease.

Authors+Show Affiliations

Institute for Immunology, Faculty of Medicine, Kyoto University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7642216

Citation

Nishio, A, et al. "Breakdown of Self-tolerance By Intrathymic Injection of a T-cell Line Inducing Autoimmune Gastritis in Mice." Immunology, vol. 85, no. 2, 1995, pp. 270-5.
Nishio A, Katakai T, Hosono M, et al. Breakdown of self-tolerance by intrathymic injection of a T-cell line inducing autoimmune gastritis in mice. Immunology. 1995;85(2):270-5.
Nishio, A., Katakai, T., Hosono, M., Inaba, M., Sakai, M., Okuma, M., Kasakura, S., & Masuda, T. (1995). Breakdown of self-tolerance by intrathymic injection of a T-cell line inducing autoimmune gastritis in mice. Immunology, 85(2), 270-5.
Nishio A, et al. Breakdown of Self-tolerance By Intrathymic Injection of a T-cell Line Inducing Autoimmune Gastritis in Mice. Immunology. 1995;85(2):270-5. PubMed PMID: 7642216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breakdown of self-tolerance by intrathymic injection of a T-cell line inducing autoimmune gastritis in mice. AU - Nishio,A, AU - Katakai,T, AU - Hosono,M, AU - Inaba,M, AU - Sakai,M, AU - Okuma,M, AU - Kasakura,S, AU - Masuda,T, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 270 EP - 5 JF - Immunology JO - Immunology VL - 85 IS - 2 N2 - Autoimmune gastritis (AIG) develops spontaneously in BALB/c mice thymectomized 3 days after birth (3d-Tx). We first confirmed our previous observations that CD4+ splenic T cells in AIG mice induced AIG in nu/nu mice, while those in normal mice suppressed the development of the disease. In addition, we found that a quantitative balance between these effector (Te) and suppressor (Ts) T cells determined either onset or prevention of the disease. Peripheralization of Ts seemed to begin around 3 days after birth, since the incidence of AIG in mice that underwent Tx 6 days after birth (6d-Tx) decreased markedly, compared with that of 3d-Tx mice; 12% in the former, while 79% in the latter. Notably, Ts existed in the 6d-Tx mice that escaped AIG. We next examined the target specificity of such Ts using syngeneic parietal cells known as autoantigens and two kinds of T-cell lines established from an AIG mouse; one is gastritis inducible in vivo, termed A-II, while another is not, named AC-II. Intrathymic injection of parietal cells into mice 3 days after birth followed by 6d-Tx completely prevented the development of AIG. In contrast, injection of irradiated A-II, but not AC-II cells resulted in AIG in 67% of the mice. No autoimmune oophoritis (AIO) was induced in female mice, implying that the breakdown of tolerance is organ specific. Taken together, peripheral tolerance for organ-specific autoantigens seems to be maintained by CD4+ Ts responding to Te, which induces the disease. SN - 0019-2805 UR - https://www.unboundmedicine.com/medline/citation/7642216/Breakdown_of_self_tolerance_by_intrathymic_injection_of_a_T_cell_line_inducing_autoimmune_gastritis_in_mice_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7642216/ DB - PRIME DP - Unbound Medicine ER -