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LDL receptor activity is down-regulated similarly by a cholesterol-containing diet high in palmitic acid or high in lauric and myristic acids in cynomolgus monkeys.
J Nutr 1995; 125(8):2055-63JN

Abstract

To determine the mechanisms whereby diets differing widely in fatty acid composition affect plasma LDL cholesterol and apolipoprotein B concentrations, LDL kinetics and receptor- and nonreceptor-mediated LDL catabolism were investigated in 27 cynomolgus monkeys fed diets containing 0.05 mg cholesterol/kJ and 40% fat energy as corn oil alone (unsaturated fat diet rich in oleic and linoleic acids), nonhydrogenated coconut oil alone (saturated fat diet, rich in lauric and myristic acids) or an oil blend (rich in palmitic acid). Consumption of the oil blend and saturated fat diets significantly elevated total cholesterol, LDL cholesterol and apolipoprotein B concentrations relative to the unsaturated fat diet and the saturated fat diet significantly increased plasma total cholesterol and LDL cholesterol compared with the oil blend diet. However, despite the greater increases in plasma total cholesterol, LDL cholesterol and apolipoprotein B in the saturated fat vs. the oil blend dietary group, the receptor-mediated LDL fractional catabolic rate was comparable in the oil blend and saturated fat diet groups. In addition, consumption of the oil blend or saturated fat diet increased the production rate of LDL apolipoprotein B and nonreceptor-mediated LDL apolipoprotein B transport (disposal) relative to the unsaturated fat diet. Our data, therefore, suggest that consumption of the oil blend or saturated fat diet elevated plasma total cholesterol and LDL cholesterol relative to the unsaturated fat diet, and the oil blend diet abundant in palmitic acid seems to have down-regulated the LDL receptor as much as a more saturated fat diet abundant in lauric and myristic acids.

Authors+Show Affiliations

Department of Clinical Sciences, University of Massachusetts-Lowell 01854, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7643239

Citation

Stucchi, A F., et al. "LDL Receptor Activity Is Down-regulated Similarly By a Cholesterol-containing Diet High in Palmitic Acid or High in Lauric and Myristic Acids in Cynomolgus Monkeys." The Journal of Nutrition, vol. 125, no. 8, 1995, pp. 2055-63.
Stucchi AF, Terpstra AH, Nicolosi RJ. LDL receptor activity is down-regulated similarly by a cholesterol-containing diet high in palmitic acid or high in lauric and myristic acids in cynomolgus monkeys. J Nutr. 1995;125(8):2055-63.
Stucchi, A. F., Terpstra, A. H., & Nicolosi, R. J. (1995). LDL receptor activity is down-regulated similarly by a cholesterol-containing diet high in palmitic acid or high in lauric and myristic acids in cynomolgus monkeys. The Journal of Nutrition, 125(8), pp. 2055-63.
Stucchi AF, Terpstra AH, Nicolosi RJ. LDL Receptor Activity Is Down-regulated Similarly By a Cholesterol-containing Diet High in Palmitic Acid or High in Lauric and Myristic Acids in Cynomolgus Monkeys. J Nutr. 1995;125(8):2055-63. PubMed PMID: 7643239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - LDL receptor activity is down-regulated similarly by a cholesterol-containing diet high in palmitic acid or high in lauric and myristic acids in cynomolgus monkeys. AU - Stucchi,A F, AU - Terpstra,A H, AU - Nicolosi,R J, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 2055 EP - 63 JF - The Journal of nutrition JO - J. Nutr. VL - 125 IS - 8 N2 - To determine the mechanisms whereby diets differing widely in fatty acid composition affect plasma LDL cholesterol and apolipoprotein B concentrations, LDL kinetics and receptor- and nonreceptor-mediated LDL catabolism were investigated in 27 cynomolgus monkeys fed diets containing 0.05 mg cholesterol/kJ and 40% fat energy as corn oil alone (unsaturated fat diet rich in oleic and linoleic acids), nonhydrogenated coconut oil alone (saturated fat diet, rich in lauric and myristic acids) or an oil blend (rich in palmitic acid). Consumption of the oil blend and saturated fat diets significantly elevated total cholesterol, LDL cholesterol and apolipoprotein B concentrations relative to the unsaturated fat diet and the saturated fat diet significantly increased plasma total cholesterol and LDL cholesterol compared with the oil blend diet. However, despite the greater increases in plasma total cholesterol, LDL cholesterol and apolipoprotein B in the saturated fat vs. the oil blend dietary group, the receptor-mediated LDL fractional catabolic rate was comparable in the oil blend and saturated fat diet groups. In addition, consumption of the oil blend or saturated fat diet increased the production rate of LDL apolipoprotein B and nonreceptor-mediated LDL apolipoprotein B transport (disposal) relative to the unsaturated fat diet. Our data, therefore, suggest that consumption of the oil blend or saturated fat diet elevated plasma total cholesterol and LDL cholesterol relative to the unsaturated fat diet, and the oil blend diet abundant in palmitic acid seems to have down-regulated the LDL receptor as much as a more saturated fat diet abundant in lauric and myristic acids. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/7643239/LDL_receptor_activity_is_down_regulated_similarly_by_a_cholesterol_containing_diet_high_in_palmitic_acid_or_high_in_lauric_and_myristic_acids_in_cynomolgus_monkeys_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/125.8.2055 DB - PRIME DP - Unbound Medicine ER -