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Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study.
Prev Med. 1995 May; 24(3):308-15.PM

Abstract

BACKGROUND

In the Seven Countries Study associations between intake of individual fatty acids and dietary cholesterol were studied in relation to serum cholesterol and 25-year mortality from coronary heart disease. All analyses concern only intercohort comparisons.

METHODS

In the baseline surveys carried out between 1958 and 1964, risk factors for coronary heart disease were measured among 12,763 middle-aged men constituting 16 cohorts in seven countries. In 1987 and 1988 equivalent food composites representing the average food intake of each cohort at baseline were collected locally and analyzed in a central laboratory. The vital status of all participants was verified at regular intervals during 25 years of follow-up.

RESULTS

Of the individual saturated fatty acids, the average population intake of lauric and myristic acid was most strongly related to the average serum cholesterol level (r > 0.8, P < 0.001). Strong positive associations were observed between 25-year death rates from coronary heart disease and average intake of the four major saturated fatty acids, lauric, myristic, palmitic, and stearic acid (r > 0.8, P < 0.001); the trans fatty acid elaidic acid (r = 0.78, P < 0.001); and dietary cholesterol (r = 0.55, P < 0.05).

CONCLUSIONS

Interpreted in the light of experimental and clinical studies, the results of these cross-cultural analyses suggest that dietary saturated and trans fatty acids and dietary cholesterol are important determinants of differences in population rates of coronary heart disease death.

Authors+Show Affiliations

Division of Public Health Research, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7644455

Citation

Kromhout, D, et al. "Dietary Saturated and Trans Fatty Acids and Cholesterol and 25-year Mortality From Coronary Heart Disease: the Seven Countries Study." Preventive Medicine, vol. 24, no. 3, 1995, pp. 308-15.
Kromhout D, Menotti A, Bloemberg B, et al. Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. Prev Med. 1995;24(3):308-15.
Kromhout, D., Menotti, A., Bloemberg, B., Aravanis, C., Blackburn, H., Buzina, R., Dontas, A. S., Fidanza, F., Giampaoli, S., & Jansen, A. (1995). Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. Preventive Medicine, 24(3), 308-15.
Kromhout D, et al. Dietary Saturated and Trans Fatty Acids and Cholesterol and 25-year Mortality From Coronary Heart Disease: the Seven Countries Study. Prev Med. 1995;24(3):308-15. PubMed PMID: 7644455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. A1 - Kromhout,D, AU - Menotti,A, AU - Bloemberg,B, AU - Aravanis,C, AU - Blackburn,H, AU - Buzina,R, AU - Dontas,A S, AU - Fidanza,F, AU - Giampaoli,S, AU - Jansen,A, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 308 EP - 15 JF - Preventive medicine JO - Prev Med VL - 24 IS - 3 N2 - BACKGROUND: In the Seven Countries Study associations between intake of individual fatty acids and dietary cholesterol were studied in relation to serum cholesterol and 25-year mortality from coronary heart disease. All analyses concern only intercohort comparisons. METHODS: In the baseline surveys carried out between 1958 and 1964, risk factors for coronary heart disease were measured among 12,763 middle-aged men constituting 16 cohorts in seven countries. In 1987 and 1988 equivalent food composites representing the average food intake of each cohort at baseline were collected locally and analyzed in a central laboratory. The vital status of all participants was verified at regular intervals during 25 years of follow-up. RESULTS: Of the individual saturated fatty acids, the average population intake of lauric and myristic acid was most strongly related to the average serum cholesterol level (r > 0.8, P < 0.001). Strong positive associations were observed between 25-year death rates from coronary heart disease and average intake of the four major saturated fatty acids, lauric, myristic, palmitic, and stearic acid (r > 0.8, P < 0.001); the trans fatty acid elaidic acid (r = 0.78, P < 0.001); and dietary cholesterol (r = 0.55, P < 0.05). CONCLUSIONS: Interpreted in the light of experimental and clinical studies, the results of these cross-cultural analyses suggest that dietary saturated and trans fatty acids and dietary cholesterol are important determinants of differences in population rates of coronary heart disease death. SN - 0091-7435 UR - https://www.unboundmedicine.com/medline/citation/7644455/Dietary_saturated_and_trans_fatty_acids_and_cholesterol_and_25_year_mortality_from_coronary_heart_disease:_the_Seven_Countries_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091743585710493 DB - PRIME DP - Unbound Medicine ER -