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Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy.
Br J Surg. 1995 Aug; 82(8):1034-5.BJ

Abstract

A prospective randomized controlled trial was carried out on the effects of Daflon 500 mg (a micronized flavonidic fraction containing diosmin 450 mg and hesperidin 50 mg) on bleeding after haemorrhoidectomy. In all, 228 consecutive patients with prolapsed irreducible piles were recruited. Elective haemorrhoidectomy was performed with a standardized diathermy excision method. Some 114 patients were randomized to receive Daflon 500 mg for 1 week after operation (group 1), and there were 114 controls (group 2). Postoperative analgesia and laxative prescription as well as hospital stay were otherwise the same. One patient (0.9 per cent) from group 1 and seven (6.1 per cent) from group 2 had postoperative bleeding (P = 0.03). All bleeding occurred from 6 to 15 days after haemorrhoidectomy. There were no side-effects from the use of Daflon 500 mg. The risk of secondary bleeding from haemorrhoidectomy is reduced with postoperative Daflon.

Authors+Show Affiliations

Department of Colorectal Surgery, Singapore General Hospital.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7648143

Citation

Ho, Y H., et al. "Prospective Randomized Controlled Trial of a Micronized Flavonidic Fraction to Reduce Bleeding After Haemorrhoidectomy." The British Journal of Surgery, vol. 82, no. 8, 1995, pp. 1034-5.
Ho YH, Foo CL, Seow-Choen F, et al. Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy. Br J Surg. 1995;82(8):1034-5.
Ho, Y. H., Foo, C. L., Seow-Choen, F., & Goh, H. S. (1995). Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy. The British Journal of Surgery, 82(8), 1034-5.
Ho YH, et al. Prospective Randomized Controlled Trial of a Micronized Flavonidic Fraction to Reduce Bleeding After Haemorrhoidectomy. Br J Surg. 1995;82(8):1034-5. PubMed PMID: 7648143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy. AU - Ho,Y H, AU - Foo,C L, AU - Seow-Choen,F, AU - Goh,H S, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 1034 EP - 5 JF - The British journal of surgery JO - Br J Surg VL - 82 IS - 8 N2 - A prospective randomized controlled trial was carried out on the effects of Daflon 500 mg (a micronized flavonidic fraction containing diosmin 450 mg and hesperidin 50 mg) on bleeding after haemorrhoidectomy. In all, 228 consecutive patients with prolapsed irreducible piles were recruited. Elective haemorrhoidectomy was performed with a standardized diathermy excision method. Some 114 patients were randomized to receive Daflon 500 mg for 1 week after operation (group 1), and there were 114 controls (group 2). Postoperative analgesia and laxative prescription as well as hospital stay were otherwise the same. One patient (0.9 per cent) from group 1 and seven (6.1 per cent) from group 2 had postoperative bleeding (P = 0.03). All bleeding occurred from 6 to 15 days after haemorrhoidectomy. There were no side-effects from the use of Daflon 500 mg. The risk of secondary bleeding from haemorrhoidectomy is reduced with postoperative Daflon. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/7648143/Prospective_randomized_controlled_trial_of_a_micronized_flavonidic_fraction_to_reduce_bleeding_after_haemorrhoidectomy_ DB - PRIME DP - Unbound Medicine ER -