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Changes in erythroblast morphology as an index of response to cyanocobalamin in patients with megaloblastic anaemia.
Br J Haematol. 1975 Sep; 31(1):77-85.BJ

Abstract

Fifty-three patients with megaloblastic anaemia treated with cyanocobalamin and folic acid have been studied. Repeat marrow examination was found to be of value in assessing response to treatment. The early improvement in marrow morphology in patients with pernicious anaemia was greater with 1000 mug than with 5 mug doses of cyanocobalamin. The effect of folate deficiency in delaying marrow response to cyanocobalamin in patients with pernicious anaemia is described and combined cyanocobalamin and folic acid treatment was found to be more effective than either alone. The response to large doses of cyanocobalamin in folate deficient patients was unrelated to the initial serum vitamin B12 level.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

764853

Citation

Dawson, D W., et al. "Changes in Erythroblast Morphology as an Index of Response to Cyanocobalamin in Patients With Megaloblastic Anaemia." British Journal of Haematology, vol. 31, no. 1, 1975, pp. 77-85.
Dawson DW, Lewis MJ, Wadsworth LD. Changes in erythroblast morphology as an index of response to cyanocobalamin in patients with megaloblastic anaemia. Br J Haematol. 1975;31(1):77-85.
Dawson, D. W., Lewis, M. J., & Wadsworth, L. D. (1975). Changes in erythroblast morphology as an index of response to cyanocobalamin in patients with megaloblastic anaemia. British Journal of Haematology, 31(1), 77-85.
Dawson DW, Lewis MJ, Wadsworth LD. Changes in Erythroblast Morphology as an Index of Response to Cyanocobalamin in Patients With Megaloblastic Anaemia. Br J Haematol. 1975;31(1):77-85. PubMed PMID: 764853.
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TY - JOUR T1 - Changes in erythroblast morphology as an index of response to cyanocobalamin in patients with megaloblastic anaemia. AU - Dawson,D W, AU - Lewis,M J, AU - Wadsworth,L D, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 77 EP - 85 JF - British journal of haematology JO - Br J Haematol VL - 31 IS - 1 N2 - Fifty-three patients with megaloblastic anaemia treated with cyanocobalamin and folic acid have been studied. Repeat marrow examination was found to be of value in assessing response to treatment. The early improvement in marrow morphology in patients with pernicious anaemia was greater with 1000 mug than with 5 mug doses of cyanocobalamin. The effect of folate deficiency in delaying marrow response to cyanocobalamin in patients with pernicious anaemia is described and combined cyanocobalamin and folic acid treatment was found to be more effective than either alone. The response to large doses of cyanocobalamin in folate deficient patients was unrelated to the initial serum vitamin B12 level. SN - 0007-1048 UR - https://www.unboundmedicine.com/medline/citation/764853/Changes_in_erythroblast_morphology_as_an_index_of_response_to_cyanocobalamin_in_patients_with_megaloblastic_anaemia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1048&date=1975&volume=31&issue=1&spage=77 DB - PRIME DP - Unbound Medicine ER -