Tags

Type your tag names separated by a space and hit enter

The natural course of microalbuminuria in insulin-dependent diabetes: a 10-year prospective study.

Abstract

The purpose of this study was to describe the clinical course in patients followed right from the onset of microalbuminuria to the development of diabetic nephropathy. A 10-year prospective follow-up of 209 consecutive normotensive insulin-dependent diabetic patients with normal urinary albumin excretion (UAE < 30 mg 24 h-1), age 34 (18-50) years and duration of diabetes 17 (10-30) years was performed. Twenty-four-hour urinary albumin excretion was measured every 4 months, glycated haemoglobin and supine blood pressure was measured annually. Two-hundred (96%) patients completed 10 (range 5-10) years follow-up. Twenty-nine (15%) patients developed persistent microalbuminuria (UAE 30-300 mg 24 h-1). Eight of these have progressed to nephropathy and one had died of diabetic nephropathy. Multiple stepwise logistic regression analysis demonstrated baseline urinary albumin excretion (p = 0.0016) and glycated haemoglobin (p = 0.0014) but not blood pressure as predictors of development of microalbuminuria within the following 10 years. The median annual increase in urinary albumin excretion was 27 (range 17-65) % in the 29 patients developing microalbuminuria. The median duration from onset of microalbuminuria to development of nephropathy was 7 years. The prevalence of patients receiving antihypertensive treatment (BP > 140/90 mmHg) increased from 10% at onset of microalbuminuria to 45% 4 years after onset of microalbuminuria. The prevalence of patients with proliferative retinopathy increased from 7% at onset of microalbuminuria to 28% 4 years after onset of microalbuminuria.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Links

Authors+Show Affiliations

,

Steno Diabetes Center, Copenhagen, Denmark.

, , ,

Source

MeSH

Adolescent
Adult
Albuminuria
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Diabetic Retinopathy
Female
Follow-Up Studies
Humans
Logistic Models
Male
Middle Aged
Prospective Studies
Risk Factors
Treatment Outcome

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7648820

Citation

Mathiesen, E R., et al. "The Natural Course of Microalbuminuria in Insulin-dependent Diabetes: a 10-year Prospective Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 12, no. 6, 1995, pp. 482-7.
Mathiesen ER, Rønn B, Storm B, et al. The natural course of microalbuminuria in insulin-dependent diabetes: a 10-year prospective study. Diabet Med. 1995;12(6):482-7.
Mathiesen, E. R., Rønn, B., Storm, B., Foght, H., & Deckert, T. (1995). The natural course of microalbuminuria in insulin-dependent diabetes: a 10-year prospective study. Diabetic Medicine : a Journal of the British Diabetic Association, 12(6), pp. 482-7.
Mathiesen ER, et al. The Natural Course of Microalbuminuria in Insulin-dependent Diabetes: a 10-year Prospective Study. Diabet Med. 1995;12(6):482-7. PubMed PMID: 7648820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The natural course of microalbuminuria in insulin-dependent diabetes: a 10-year prospective study. AU - Mathiesen,E R, AU - Rønn,B, AU - Storm,B, AU - Foght,H, AU - Deckert,T, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 482 EP - 7 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 12 IS - 6 N2 - The purpose of this study was to describe the clinical course in patients followed right from the onset of microalbuminuria to the development of diabetic nephropathy. A 10-year prospective follow-up of 209 consecutive normotensive insulin-dependent diabetic patients with normal urinary albumin excretion (UAE < 30 mg 24 h-1), age 34 (18-50) years and duration of diabetes 17 (10-30) years was performed. Twenty-four-hour urinary albumin excretion was measured every 4 months, glycated haemoglobin and supine blood pressure was measured annually. Two-hundred (96%) patients completed 10 (range 5-10) years follow-up. Twenty-nine (15%) patients developed persistent microalbuminuria (UAE 30-300 mg 24 h-1). Eight of these have progressed to nephropathy and one had died of diabetic nephropathy. Multiple stepwise logistic regression analysis demonstrated baseline urinary albumin excretion (p = 0.0016) and glycated haemoglobin (p = 0.0014) but not blood pressure as predictors of development of microalbuminuria within the following 10 years. The median annual increase in urinary albumin excretion was 27 (range 17-65) % in the 29 patients developing microalbuminuria. The median duration from onset of microalbuminuria to development of nephropathy was 7 years. The prevalence of patients receiving antihypertensive treatment (BP > 140/90 mmHg) increased from 10% at onset of microalbuminuria to 45% 4 years after onset of microalbuminuria. The prevalence of patients with proliferative retinopathy increased from 7% at onset of microalbuminuria to 28% 4 years after onset of microalbuminuria.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/7648820/The_natural_course_of_microalbuminuria_in_insulin_dependent_diabetes:_a_10_year_prospective_study_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -