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Plasma and lipoprotein lipid peroxidation in humans on sunflower and rapeseed oil diets.
Lipids. 1995 Jun; 30(6):485-92.L

Abstract

The effects of natural mixed diets on lipid peroxidation were investigated in humans. In the first study, 59 subjects were fed a rapeseed oil-based diet rich in monounsaturated fatty acids (MUFA) and a sunflower oil-based diet rich in polyunsaturated fatty acids (PUFA) in a cross-over manner for three and a half weeks. The lipid peroxidation products in plasma were determined by measuring conjugated dienes and malondialdehyde (MDA). In a second study, plasma thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides, and the susceptibility of very low density lipoprotein+low-density lipoprotein (LDL) to in vitro oxidation were measured from subjects fed similar MUFA and PUFA diets for six weeks diets. No significant differences in plasma MDA or conjugated diene concentrations were found after the rapeseed oil diet or the sunflower oil diet in Study 1. In the second study, a small but significant decrease (P < 0.05) in both lipid hydroperoxides and TBARS was observed in the LDL fraction after the sunflower oil diet. The in vitro oxidation gave opposite results, showing increased oxidation after the sunflower oil diet. Despite a high intake of alpha-tocopherol during the oil periods, no increase in plasma alpha-tocopherol was noticed in either study. The results suggest that moderate changes in the fatty acid composition in the Western-type diet may be adequate to affect lipoprotein susceptibility to oxidation in vitro, but there is considerable disparity with some indices of in vivo lipid peroxidation.

Authors+Show Affiliations

Department of Applied Chemistry and Microbiology, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7651074

Citation

Turpeinen, A M., et al. "Plasma and Lipoprotein Lipid Peroxidation in Humans On Sunflower and Rapeseed Oil Diets." Lipids, vol. 30, no. 6, 1995, pp. 485-92.
Turpeinen AM, Alfthan G, Valsta L, et al. Plasma and lipoprotein lipid peroxidation in humans on sunflower and rapeseed oil diets. Lipids. 1995;30(6):485-92.
Turpeinen, A. M., Alfthan, G., Valsta, L., Hietanen, E., Salonen, J. T., Schunk, H., Nyyssönen, K., & Mutanen, M. (1995). Plasma and lipoprotein lipid peroxidation in humans on sunflower and rapeseed oil diets. Lipids, 30(6), 485-92.
Turpeinen AM, et al. Plasma and Lipoprotein Lipid Peroxidation in Humans On Sunflower and Rapeseed Oil Diets. Lipids. 1995;30(6):485-92. PubMed PMID: 7651074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma and lipoprotein lipid peroxidation in humans on sunflower and rapeseed oil diets. AU - Turpeinen,A M, AU - Alfthan,G, AU - Valsta,L, AU - Hietanen,E, AU - Salonen,J T, AU - Schunk,H, AU - Nyyssönen,K, AU - Mutanen,M, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 485 EP - 92 JF - Lipids JO - Lipids VL - 30 IS - 6 N2 - The effects of natural mixed diets on lipid peroxidation were investigated in humans. In the first study, 59 subjects were fed a rapeseed oil-based diet rich in monounsaturated fatty acids (MUFA) and a sunflower oil-based diet rich in polyunsaturated fatty acids (PUFA) in a cross-over manner for three and a half weeks. The lipid peroxidation products in plasma were determined by measuring conjugated dienes and malondialdehyde (MDA). In a second study, plasma thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides, and the susceptibility of very low density lipoprotein+low-density lipoprotein (LDL) to in vitro oxidation were measured from subjects fed similar MUFA and PUFA diets for six weeks diets. No significant differences in plasma MDA or conjugated diene concentrations were found after the rapeseed oil diet or the sunflower oil diet in Study 1. In the second study, a small but significant decrease (P < 0.05) in both lipid hydroperoxides and TBARS was observed in the LDL fraction after the sunflower oil diet. The in vitro oxidation gave opposite results, showing increased oxidation after the sunflower oil diet. Despite a high intake of alpha-tocopherol during the oil periods, no increase in plasma alpha-tocopherol was noticed in either study. The results suggest that moderate changes in the fatty acid composition in the Western-type diet may be adequate to affect lipoprotein susceptibility to oxidation in vitro, but there is considerable disparity with some indices of in vivo lipid peroxidation. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/7651074/Plasma_and_lipoprotein_lipid_peroxidation_in_humans_on_sunflower_and_rapeseed_oil_diets_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0024-4201&amp;date=1995&amp;volume=30&amp;issue=6&amp;spage=485 DB - PRIME DP - Unbound Medicine ER -