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"Pure" striatonigral degeneration and Parkinson's disease: a comparative clinical study.
Mov Disord. 1995 May; 10(3):288-94.MD

Abstract

Striatonigral degeneration (SND) is difficult to diagnose in vivo. The purpose of this study was to detect the best indicators for an early and reliable diagnosis of the disease. Eighteen patients clinically diagnosed as having SND were selected with rigorous inclusion criteria and compared to 18 patients with Parkinson's disease (PD) matched for age and disease duration. Apart from dysautonomia, the principal discriminant clinical features that distinguished SND from PD were the early appearance of the following symptoms and signs: (a) severe and atypical progressive parkinsonism characterized by bilateral bradykinesia and rigidity, slowness of gait, postural instability, and falls, and poor or absent response to adequate levodopa treatment; (b) increased tendon reflexes associated or not with frank pyramidal signs, severe dysarthria, and less consistently, dysphagia, stridor, antecollis, and stimulus-sensitive myoclonus, which, when present, are highly suggestive of the disease.

Authors+Show Affiliations

INSERM U 289, Hópital de la Salpétrière, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7651445

Citation

Gouider-Khouja, N, et al. ""Pure" Striatonigral Degeneration and Parkinson's Disease: a Comparative Clinical Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 10, no. 3, 1995, pp. 288-94.
Gouider-Khouja N, Vidailhet M, Bonnet AM, et al. "Pure" striatonigral degeneration and Parkinson's disease: a comparative clinical study. Mov Disord. 1995;10(3):288-94.
Gouider-Khouja, N., Vidailhet, M., Bonnet, A. M., Pichon, J., & Agid, Y. (1995). "Pure" striatonigral degeneration and Parkinson's disease: a comparative clinical study. Movement Disorders : Official Journal of the Movement Disorder Society, 10(3), 288-94.
Gouider-Khouja N, et al. "Pure" Striatonigral Degeneration and Parkinson's Disease: a Comparative Clinical Study. Mov Disord. 1995;10(3):288-94. PubMed PMID: 7651445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - "Pure" striatonigral degeneration and Parkinson's disease: a comparative clinical study. AU - Gouider-Khouja,N, AU - Vidailhet,M, AU - Bonnet,A M, AU - Pichon,J, AU - Agid,Y, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 288 EP - 94 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 10 IS - 3 N2 - Striatonigral degeneration (SND) is difficult to diagnose in vivo. The purpose of this study was to detect the best indicators for an early and reliable diagnosis of the disease. Eighteen patients clinically diagnosed as having SND were selected with rigorous inclusion criteria and compared to 18 patients with Parkinson's disease (PD) matched for age and disease duration. Apart from dysautonomia, the principal discriminant clinical features that distinguished SND from PD were the early appearance of the following symptoms and signs: (a) severe and atypical progressive parkinsonism characterized by bilateral bradykinesia and rigidity, slowness of gait, postural instability, and falls, and poor or absent response to adequate levodopa treatment; (b) increased tendon reflexes associated or not with frank pyramidal signs, severe dysarthria, and less consistently, dysphagia, stridor, antecollis, and stimulus-sensitive myoclonus, which, when present, are highly suggestive of the disease. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/7651445/"Pure"_striatonigral_degeneration_and_Parkinson's_disease:_a_comparative_clinical_study_ DB - PRIME DP - Unbound Medicine ER -