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Inhibitors of protein kinases induce differentiation in human neuroblastoma cell lines.
Anticancer Res. 1995 Jul-Aug; 15(4):1381-5.AR

Abstract

We investigated the effect on differentiation of genistein, an inhibitor of tyrosine protein kinase, and 1-(-5 isoquinolinylsulfonyl)-2-methylpiperazine (H7), an inhibitor of protein kinase C, in neuroblastoma cell lines. Growth inhibition and expression of morphological and biochemical properties were examined in the human neuroblastoma cell lines TS12 and SJNKP. Genistein and H7 induced neurite outgrowth, increased acetylcholinesterase activity and cell growth inhibition in both cell lines. These results underline that tyrosine protein kinase and protein kinase C may play a key role in the control of differentiation and proliferation of neural cells.

Authors+Show Affiliations

Centro Interdipartimentale di Ricerche sul Cancro Giorgio Prodi, Università di Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7654025

Citation

Rocchi, P, et al. "Inhibitors of Protein Kinases Induce Differentiation in Human Neuroblastoma Cell Lines." Anticancer Research, vol. 15, no. 4, 1995, pp. 1381-5.
Rocchi P, Ferreri AM, Simone G, et al. Inhibitors of protein kinases induce differentiation in human neuroblastoma cell lines. Anticancer Res. 1995;15(4):1381-5.
Rocchi, P., Ferreri, A. M., Simone, G., Magrini, E., Cavallazzi, L., & Paolucci, G. (1995). Inhibitors of protein kinases induce differentiation in human neuroblastoma cell lines. Anticancer Research, 15(4), 1381-5.
Rocchi P, et al. Inhibitors of Protein Kinases Induce Differentiation in Human Neuroblastoma Cell Lines. Anticancer Res. 1995 Jul-Aug;15(4):1381-5. PubMed PMID: 7654025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitors of protein kinases induce differentiation in human neuroblastoma cell lines. AU - Rocchi,P, AU - Ferreri,A M, AU - Simone,G, AU - Magrini,E, AU - Cavallazzi,L, AU - Paolucci,G, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 1381 EP - 5 JF - Anticancer research JO - Anticancer Res VL - 15 IS - 4 N2 - We investigated the effect on differentiation of genistein, an inhibitor of tyrosine protein kinase, and 1-(-5 isoquinolinylsulfonyl)-2-methylpiperazine (H7), an inhibitor of protein kinase C, in neuroblastoma cell lines. Growth inhibition and expression of morphological and biochemical properties were examined in the human neuroblastoma cell lines TS12 and SJNKP. Genistein and H7 induced neurite outgrowth, increased acetylcholinesterase activity and cell growth inhibition in both cell lines. These results underline that tyrosine protein kinase and protein kinase C may play a key role in the control of differentiation and proliferation of neural cells. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/7654025/Inhibitors_of_protein_kinases_induce_differentiation_in_human_neuroblastoma_cell_lines_ L2 - http://www.diseaseinfosearch.org/result/5160 DB - PRIME DP - Unbound Medicine ER -