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Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy.
Ann Neurol. 1995 Aug; 38(2):254-9.AN

Abstract

Cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular deposition of the amyloid beta-peptide, leading to intracerebral hemorrhage in severe cases. Other than rare familial cases, the only identified risks for CAA are advancing age and accompanying Alzheimer's disease. We tested whether the apolipoprotein E epsilon 4 (apoE epsilon 4) allele was associated with CAA and hemorrhage and whether this association was independent of Alzheimer's disease. The apoE epsilon 4 genotype was determined without knowledge of the pathology for 93 postmortem cases systematically graded for severity of CAA and for 15 patients with CAA-associated intracerebral hemorrhage. We found a significant and independent effect of the apoE genotype in both cohorts. Among the postmortem cases, the presence of apoE epsilon 4 increased the odds ratio for moderate or severe CAA by 2.9-fold, relative to cases without epsilon 4; two copies of epsilon 4 increased the odds ratio 13.1-fold. In the cohort of CAA-associated cerebral hemorrhages, the apoE epsilon 4 allele frequency was 0.40, significantly greater than the control frequency of 0.14. The increase in CAA remained even after controlling for the presence of Alzheimer's disease, suggesting that apoE epsilon 4 is a risk factor for CAA and CAA-related hemorrhage, independent of its association with Alzheimer's disease.

Authors+Show Affiliations

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7654074

Citation

Greenberg, S M., et al. "Apolipoprotein E Epsilon 4 and Cerebral Hemorrhage Associated With Amyloid Angiopathy." Annals of Neurology, vol. 38, no. 2, 1995, pp. 254-9.
Greenberg SM, Rebeck GW, Vonsattel JP, et al. Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol. 1995;38(2):254-9.
Greenberg, S. M., Rebeck, G. W., Vonsattel, J. P., Gomez-Isla, T., & Hyman, B. T. (1995). Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Annals of Neurology, 38(2), 254-9.
Greenberg SM, et al. Apolipoprotein E Epsilon 4 and Cerebral Hemorrhage Associated With Amyloid Angiopathy. Ann Neurol. 1995;38(2):254-9. PubMed PMID: 7654074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. AU - Greenberg,S M, AU - Rebeck,G W, AU - Vonsattel,J P, AU - Gomez-Isla,T, AU - Hyman,B T, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 254 EP - 9 JF - Annals of neurology JO - Ann. Neurol. VL - 38 IS - 2 N2 - Cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular deposition of the amyloid beta-peptide, leading to intracerebral hemorrhage in severe cases. Other than rare familial cases, the only identified risks for CAA are advancing age and accompanying Alzheimer's disease. We tested whether the apolipoprotein E epsilon 4 (apoE epsilon 4) allele was associated with CAA and hemorrhage and whether this association was independent of Alzheimer's disease. The apoE epsilon 4 genotype was determined without knowledge of the pathology for 93 postmortem cases systematically graded for severity of CAA and for 15 patients with CAA-associated intracerebral hemorrhage. We found a significant and independent effect of the apoE genotype in both cohorts. Among the postmortem cases, the presence of apoE epsilon 4 increased the odds ratio for moderate or severe CAA by 2.9-fold, relative to cases without epsilon 4; two copies of epsilon 4 increased the odds ratio 13.1-fold. In the cohort of CAA-associated cerebral hemorrhages, the apoE epsilon 4 allele frequency was 0.40, significantly greater than the control frequency of 0.14. The increase in CAA remained even after controlling for the presence of Alzheimer's disease, suggesting that apoE epsilon 4 is a risk factor for CAA and CAA-related hemorrhage, independent of its association with Alzheimer's disease. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/7654074/Apolipoprotein_E_epsilon_4_and_cerebral_hemorrhage_associated_with_amyloid_angiopathy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1995&volume=38&issue=2&spage=254 DB - PRIME DP - Unbound Medicine ER -