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Prognostic factors for relapse and maintenance treatment with cisapride in gastro-oesophageal reflux disease.
Aliment Pharmacol Ther. 1995 Jun; 9(3):271-80.AP

Abstract

AIM

To perform a further Cox proportional hazards logistic regression analysis of data from two large-scale placebo-controlled trials with cisapride as maintenance treatment in reflux disease.

RESULTS

Analysis of each of the two databases, allowing the model to operate freely, led to the identification of a number of unexpected putative predictors of outcome in the 6 to 12 months following initial healing of oesophagitis with an H2-receptor antagonist or omeprazole. This allowed us to delineate more accurately the patient population that is likely to respond to long-term continuous treatment with low or standard dose cisapride. The analysis revealed that symptom severity may be more useful than endoscopic severity in predicting relapse or in guiding therapy. Reflux oesophagitis outcome is particularly poor in the presence of treatment-recalcitrant symptoms or severe mucosal damage. Analysis showed cisapride to be effective in the maintenance treatment of patients with non-refractory symptoms, irrespective of the initial severity of oesophagitis, the healing agent used, or a history of previous endoscopic relapses.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7654889

Citation

Tytgat, G N., et al. "Prognostic Factors for Relapse and Maintenance Treatment With Cisapride in Gastro-oesophageal Reflux Disease." Alimentary Pharmacology & Therapeutics, vol. 9, no. 3, 1995, pp. 271-80.
Tytgat GN, Blum AL, Verlinden M. Prognostic factors for relapse and maintenance treatment with cisapride in gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 1995;9(3):271-80.
Tytgat, G. N., Blum, A. L., & Verlinden, M. (1995). Prognostic factors for relapse and maintenance treatment with cisapride in gastro-oesophageal reflux disease. Alimentary Pharmacology & Therapeutics, 9(3), 271-80.
Tytgat GN, Blum AL, Verlinden M. Prognostic Factors for Relapse and Maintenance Treatment With Cisapride in Gastro-oesophageal Reflux Disease. Aliment Pharmacol Ther. 1995;9(3):271-80. PubMed PMID: 7654889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic factors for relapse and maintenance treatment with cisapride in gastro-oesophageal reflux disease. AU - Tytgat,G N, AU - Blum,A L, AU - Verlinden,M, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 271 EP - 80 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 9 IS - 3 N2 - AIM: To perform a further Cox proportional hazards logistic regression analysis of data from two large-scale placebo-controlled trials with cisapride as maintenance treatment in reflux disease. RESULTS: Analysis of each of the two databases, allowing the model to operate freely, led to the identification of a number of unexpected putative predictors of outcome in the 6 to 12 months following initial healing of oesophagitis with an H2-receptor antagonist or omeprazole. This allowed us to delineate more accurately the patient population that is likely to respond to long-term continuous treatment with low or standard dose cisapride. The analysis revealed that symptom severity may be more useful than endoscopic severity in predicting relapse or in guiding therapy. Reflux oesophagitis outcome is particularly poor in the presence of treatment-recalcitrant symptoms or severe mucosal damage. Analysis showed cisapride to be effective in the maintenance treatment of patients with non-refractory symptoms, irrespective of the initial severity of oesophagitis, the healing agent used, or a history of previous endoscopic relapses. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/7654889/Prognostic_factors_for_relapse_and_maintenance_treatment_with_cisapride_in_gastro_oesophageal_reflux_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=1995&volume=9&issue=3&spage=271 DB - PRIME DP - Unbound Medicine ER -