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Application of a bedside whole blood D-dimer assay in the diagnosis of deep vein thrombosis.
Blood Coagul Fibrinolysis. 1995 May; 6(3):219-22.BC

Abstract

Cross-linked fibrin degradation products have been used to detect venous thrombosis. While the sensitivity of plasma D-dimer measured by ELISA in the diagnosis of deep vein thrombosis (DVT) is high, the utility of ELISA methods is limited in a clinical setting. This study analysed the diagnostic value of a rapid D-dimer assay performed on whole blood samples (SimpliRed D-dimer) compared with latex and ELISA in 86 patients suspected of having DVT. SimpliRed D-dimer was positive in 47/50 of patients with DVT established by Doppler ultrasound (DU; sensitivity 94%). SimpliRed D-dimer was positive in 35/37 of patients with proximal DVT, nine out of nine with popliteal DVT and three out of four with superficial thrombophlebitis. The specificity of SimpliRed D-dimer in the diagnosis of DVT was 61%. The sensitivity of the SimpliRed D-dimer assay was at least comparable with the ELISA (87%) and superior to the latex assay (80%). The positive predictive value (77%), the negative predictive value (88%) and the overall accuracy (80%) of the SimpliRed assay were better than the ELISA and latex methods. It is concluded that SimpliRed D-dimer is a rapid useful assay for screening of patients suspected of having deep vein thrombosis.

Authors+Show Affiliations

Thrombosis and Hemostasis Unit, Rambam Medical Center, and Faculty of Medicine, Technion, Haifa, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7654935

Citation

Brenner, B, et al. "Application of a Bedside Whole Blood D-dimer Assay in the Diagnosis of Deep Vein Thrombosis." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 6, no. 3, 1995, pp. 219-22.
Brenner B, Pery M, Lanir N, et al. Application of a bedside whole blood D-dimer assay in the diagnosis of deep vein thrombosis. Blood Coagul Fibrinolysis. 1995;6(3):219-22.
Brenner, B., Pery, M., Lanir, N., Jabareen, A., Markel, A., Kaftori, J. K., Gaitini, D., & Rylatt, D. (1995). Application of a bedside whole blood D-dimer assay in the diagnosis of deep vein thrombosis. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 6(3), 219-22.
Brenner B, et al. Application of a Bedside Whole Blood D-dimer Assay in the Diagnosis of Deep Vein Thrombosis. Blood Coagul Fibrinolysis. 1995;6(3):219-22. PubMed PMID: 7654935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Application of a bedside whole blood D-dimer assay in the diagnosis of deep vein thrombosis. AU - Brenner,B, AU - Pery,M, AU - Lanir,N, AU - Jabareen,A, AU - Markel,A, AU - Kaftori,J K, AU - Gaitini,D, AU - Rylatt,D, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 219 EP - 22 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul Fibrinolysis VL - 6 IS - 3 N2 - Cross-linked fibrin degradation products have been used to detect venous thrombosis. While the sensitivity of plasma D-dimer measured by ELISA in the diagnosis of deep vein thrombosis (DVT) is high, the utility of ELISA methods is limited in a clinical setting. This study analysed the diagnostic value of a rapid D-dimer assay performed on whole blood samples (SimpliRed D-dimer) compared with latex and ELISA in 86 patients suspected of having DVT. SimpliRed D-dimer was positive in 47/50 of patients with DVT established by Doppler ultrasound (DU; sensitivity 94%). SimpliRed D-dimer was positive in 35/37 of patients with proximal DVT, nine out of nine with popliteal DVT and three out of four with superficial thrombophlebitis. The specificity of SimpliRed D-dimer in the diagnosis of DVT was 61%. The sensitivity of the SimpliRed D-dimer assay was at least comparable with the ELISA (87%) and superior to the latex assay (80%). The positive predictive value (77%), the negative predictive value (88%) and the overall accuracy (80%) of the SimpliRed assay were better than the ELISA and latex methods. It is concluded that SimpliRed D-dimer is a rapid useful assay for screening of patients suspected of having deep vein thrombosis. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/7654935/Application_of_a_bedside_whole_blood_D_dimer_assay_in_the_diagnosis_of_deep_vein_thrombosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7654935.ui DB - PRIME DP - Unbound Medicine ER -