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[Heredity and colorectal cancer].
Minerva Chir. 1995 Mar; 50(3):167-75.MC

Abstract

Colorectal cancer is the second leading cause of death from malignancies in Western Countries. In spite of advances in treatment, little change in survival has been accomplished in last decades and this mandates greater importance to prevention and early detection. Although dietary factors have received primary attention familial clustering suggests that susceptibility to KCR is inherited. Hereditary colorectal cancer can arise on Familial Adenomatous Polyposis (HCC) or not on polyposis (HNPCC) and members of these families are at high risk of such neoplasias. Anyway, even in "sporadic" forms of KCR first-degree relatives have a 2 to 3-fold increased risk of the same cancer. The most desirable screening protocol would be a simple procedure involving only a blood test to identify gene defect by molecular biology techniques. Unfortunately, this is not practically possible, for lack of specific genetic alterations, out of FAP, and only the study of family history can enable targeted surveillance and cost-effective management strategies.

Authors+Show Affiliations

Istituto di Clinica Chirurgica, Università degli Studi, Siena.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ita

PubMed ID

7659249

Citation

Civitelli, S, et al. "[Heredity and Colorectal Cancer]." Minerva Chirurgica, vol. 50, no. 3, 1995, pp. 167-75.
Civitelli S, Civitelli B, Pacchiarotti MC, et al. [Heredity and colorectal cancer]. Minerva Chir. 1995;50(3):167-75.
Civitelli, S., Civitelli, B., Pacchiarotti, M. C., & Tanzini, G. (1995). [Heredity and colorectal cancer]. Minerva Chirurgica, 50(3), 167-75.
Civitelli S, et al. [Heredity and Colorectal Cancer]. Minerva Chir. 1995;50(3):167-75. PubMed PMID: 7659249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Heredity and colorectal cancer]. AU - Civitelli,S, AU - Civitelli,B, AU - Pacchiarotti,M C, AU - Tanzini,G, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 167 EP - 75 JF - Minerva chirurgica JO - Minerva Chir VL - 50 IS - 3 N2 - Colorectal cancer is the second leading cause of death from malignancies in Western Countries. In spite of advances in treatment, little change in survival has been accomplished in last decades and this mandates greater importance to prevention and early detection. Although dietary factors have received primary attention familial clustering suggests that susceptibility to KCR is inherited. Hereditary colorectal cancer can arise on Familial Adenomatous Polyposis (HCC) or not on polyposis (HNPCC) and members of these families are at high risk of such neoplasias. Anyway, even in "sporadic" forms of KCR first-degree relatives have a 2 to 3-fold increased risk of the same cancer. The most desirable screening protocol would be a simple procedure involving only a blood test to identify gene defect by molecular biology techniques. Unfortunately, this is not practically possible, for lack of specific genetic alterations, out of FAP, and only the study of family history can enable targeted surveillance and cost-effective management strategies. SN - 0026-4733 UR - https://www.unboundmedicine.com/medline/citation/7659249/[Heredity_and_colorectal_cancer]_ L2 - http://www.diseaseinfosearch.org/result/1746 DB - PRIME DP - Unbound Medicine ER -