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Effect of topical application of nitroglycerin on cochlear blood flow.
Am J Otolaryngol. 1995 May-Jun; 16(3):177-80.AJ

Abstract

PURPOSE

To investigate whether topical application of the vasodilator nitroglycerin would increase cochlear blood flow without adversely affecting inner ear function.

MATERIALS AND METHODS

The effect of topical application of nitroglycerin to the round window membrane on cochlear blood flow was measured in 33 guinea pigs with a laser Doppler flowmeter. Endocochlear potential, as an indicator of inner ear function, was recorded by a glass microelectrode inserted through the round window membrane in a second series of 27 guinea pigs. Blood pressure was also monitored in both experiments.

RESULTS

Low doses (0.0001 to 1 microgram) of nitroglycerin induced an increase in cochlear blood flow with no change in blood pressure. The cochlear blood flow was maximally increased by approximately 50%. A high dose (50 micrograms) of nitroglycerin induced a significant decrease in blood pressure but did not significantly affect endocochlear potential.

CONCLUSIONS

Topical application of nitroglycerin may be useful in increasing cochlear blood flow in various inner ear diseases.

Authors+Show Affiliations

Department of Otorhinolaryngology, Nagoya University School of Medicine, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7661313

Citation

Ito, A, et al. "Effect of Topical Application of Nitroglycerin On Cochlear Blood Flow." American Journal of Otolaryngology, vol. 16, no. 3, 1995, pp. 177-80.
Ito A, Nakashima T, Yanagita N. Effect of topical application of nitroglycerin on cochlear blood flow. Am J Otolaryngol. 1995;16(3):177-80.
Ito, A., Nakashima, T., & Yanagita, N. (1995). Effect of topical application of nitroglycerin on cochlear blood flow. American Journal of Otolaryngology, 16(3), 177-80.
Ito A, Nakashima T, Yanagita N. Effect of Topical Application of Nitroglycerin On Cochlear Blood Flow. Am J Otolaryngol. 1995 May-Jun;16(3):177-80. PubMed PMID: 7661313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of topical application of nitroglycerin on cochlear blood flow. AU - Ito,A, AU - Nakashima,T, AU - Yanagita,N, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 177 EP - 80 JF - American journal of otolaryngology JO - Am J Otolaryngol VL - 16 IS - 3 N2 - PURPOSE: To investigate whether topical application of the vasodilator nitroglycerin would increase cochlear blood flow without adversely affecting inner ear function. MATERIALS AND METHODS: The effect of topical application of nitroglycerin to the round window membrane on cochlear blood flow was measured in 33 guinea pigs with a laser Doppler flowmeter. Endocochlear potential, as an indicator of inner ear function, was recorded by a glass microelectrode inserted through the round window membrane in a second series of 27 guinea pigs. Blood pressure was also monitored in both experiments. RESULTS: Low doses (0.0001 to 1 microgram) of nitroglycerin induced an increase in cochlear blood flow with no change in blood pressure. The cochlear blood flow was maximally increased by approximately 50%. A high dose (50 micrograms) of nitroglycerin induced a significant decrease in blood pressure but did not significantly affect endocochlear potential. CONCLUSIONS: Topical application of nitroglycerin may be useful in increasing cochlear blood flow in various inner ear diseases. SN - 0196-0709 UR - https://www.unboundmedicine.com/medline/citation/7661313/Effect_of_topical_application_of_nitroglycerin_on_cochlear_blood_flow_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0196-0709(95)90098-5 DB - PRIME DP - Unbound Medicine ER -