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A secretory and histological study of the stomach before and after truncal vagotomy and pyloroplasty in duodenal ulcer patients.
Scand J Gastroenterol. 1976; 11(1):65-71.SJ

Abstract

In 10 patients with duodenal ulcer gastric secretion was studied after graded doses of pentagastrin before and 3 months after truncal vagotomy and pyloroplasty. In 6 patients carbacholine was also infused simultaneously with the greatest dose of pentagastrin after vagotomy. The histology of the gastric mucosa was studied in suction biopsies obtained from the corpus of the stomach before and 3 months after the operation. After truncal vagotomy with pyloroplasty the maximal pentagastrin-stimulated acid and pepsin secretion and the sensitivity of the parietal cells to pentagastrin were all reduced significantly. There was no significant increase in maximal pentagastrin-stimulated acid and pepsin secretion when carbacholine was added to pentagastrin. The average thickness of the gastric mucosa and the mean number of parietal cells per unit area of the stomach did not show any significant change, while the number of patients with deep gastritis increased significantly after vagotomy.

Authors

Roland M
No affiliation info available

MeSH

AdultAgedCarbacholDuodenal UlcerGastric JuiceGastric MucosaGastritisHumansMaleMiddle AgedPentagastrinPepsin APylorusSecretory RateVagotomy

Pub Type(s)

Journal Article

Language

eng

PubMed ID

766154

Citation

Roland, M. "A Secretory and Histological Study of the Stomach Before and After Truncal Vagotomy and Pyloroplasty in Duodenal Ulcer Patients." Scandinavian Journal of Gastroenterology, vol. 11, no. 1, 1976, pp. 65-71.
Roland M. A secretory and histological study of the stomach before and after truncal vagotomy and pyloroplasty in duodenal ulcer patients. Scand J Gastroenterol. 1976;11(1):65-71.
Roland, M. (1976). A secretory and histological study of the stomach before and after truncal vagotomy and pyloroplasty in duodenal ulcer patients. Scandinavian Journal of Gastroenterology, 11(1), 65-71.
Roland M. A Secretory and Histological Study of the Stomach Before and After Truncal Vagotomy and Pyloroplasty in Duodenal Ulcer Patients. Scand J Gastroenterol. 1976;11(1):65-71. PubMed PMID: 766154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A secretory and histological study of the stomach before and after truncal vagotomy and pyloroplasty in duodenal ulcer patients. A1 - Roland,M, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 65 EP - 71 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 11 IS - 1 N2 - In 10 patients with duodenal ulcer gastric secretion was studied after graded doses of pentagastrin before and 3 months after truncal vagotomy and pyloroplasty. In 6 patients carbacholine was also infused simultaneously with the greatest dose of pentagastrin after vagotomy. The histology of the gastric mucosa was studied in suction biopsies obtained from the corpus of the stomach before and 3 months after the operation. After truncal vagotomy with pyloroplasty the maximal pentagastrin-stimulated acid and pepsin secretion and the sensitivity of the parietal cells to pentagastrin were all reduced significantly. There was no significant increase in maximal pentagastrin-stimulated acid and pepsin secretion when carbacholine was added to pentagastrin. The average thickness of the gastric mucosa and the mean number of parietal cells per unit area of the stomach did not show any significant change, while the number of patients with deep gastritis increased significantly after vagotomy. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/766154/A_secretory_and_histological_study_of_the_stomach_before_and_after_truncal_vagotomy_and_pyloroplasty_in_duodenal_ulcer_patients_ DB - PRIME DP - Unbound Medicine ER -