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A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity.
Blood. 1995 Apr 01; 85(7):1881-7.Blood

Abstract

We report two patients with a distinctive biphenotypic hematologic disorder characterized by lymphoblastic lymphoma (LBL), eosinophilia, and myeloid malignancy and/or hyperplasia associated with a t(8;13)(p11;q11) chromosomal translocation in both bone marrow and lymph node specimens. Both patients presented with lymphadenopathy pathologically classified as LBL with a T-cell immunophenotype, myeloid hyperplasia of the bone marrow, and peripheral blood eosinophilia. The first patient achieved clinical complete remission after receiving several regimens of chemotherapy and remains disease-free 16 months after undergoing allogeneic bone marrow transplantation. The second patient developed progressive lymphadenopathy despite several courses of chemotherapy directed against non-Hodgkin's lymphoma. Eight months after his initial presentation, he developed acute myelogenous leukemia that was refractory to therapy. Comparison of these patients with four similar cases recently reported in the literature suggests that this constellation of findings constitutes a distinctive clinicopathologic syndrome. Molecular analysis of the t(8;13) translocation breakpoint may identify genes located in this region and provide insight into the pathogenesis of this interesting biphenotypic hematologic malignancy.

Authors+Show Affiliations

Department of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

7661940

Citation

Inhorn, R C., et al. "A Syndrome of Lymphoblastic Lymphoma, Eosinophilia, and Myeloid Hyperplasia/malignancy Associated With T(8;13)(p11;q11): Description of a Distinctive Clinicopathologic Entity." Blood, vol. 85, no. 7, 1995, pp. 1881-7.
Inhorn RC, Aster JC, Roach SA, et al. A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity. Blood. 1995;85(7):1881-7.
Inhorn, R. C., Aster, J. C., Roach, S. A., Slapak, C. A., Soiffer, R., Tantravahi, R., & Stone, R. M. (1995). A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity. Blood, 85(7), 1881-7.
Inhorn RC, et al. A Syndrome of Lymphoblastic Lymphoma, Eosinophilia, and Myeloid Hyperplasia/malignancy Associated With T(8;13)(p11;q11): Description of a Distinctive Clinicopathologic Entity. Blood. 1995 Apr 1;85(7):1881-7. PubMed PMID: 7661940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity. AU - Inhorn,R C, AU - Aster,J C, AU - Roach,S A, AU - Slapak,C A, AU - Soiffer,R, AU - Tantravahi,R, AU - Stone,R M, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 1881 EP - 7 JF - Blood JO - Blood VL - 85 IS - 7 N2 - We report two patients with a distinctive biphenotypic hematologic disorder characterized by lymphoblastic lymphoma (LBL), eosinophilia, and myeloid malignancy and/or hyperplasia associated with a t(8;13)(p11;q11) chromosomal translocation in both bone marrow and lymph node specimens. Both patients presented with lymphadenopathy pathologically classified as LBL with a T-cell immunophenotype, myeloid hyperplasia of the bone marrow, and peripheral blood eosinophilia. The first patient achieved clinical complete remission after receiving several regimens of chemotherapy and remains disease-free 16 months after undergoing allogeneic bone marrow transplantation. The second patient developed progressive lymphadenopathy despite several courses of chemotherapy directed against non-Hodgkin's lymphoma. Eight months after his initial presentation, he developed acute myelogenous leukemia that was refractory to therapy. Comparison of these patients with four similar cases recently reported in the literature suggests that this constellation of findings constitutes a distinctive clinicopathologic syndrome. Molecular analysis of the t(8;13) translocation breakpoint may identify genes located in this region and provide insight into the pathogenesis of this interesting biphenotypic hematologic malignancy. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/7661940/A_syndrome_of_lymphoblastic_lymphoma_eosinophilia_and_myeloid_hyperplasia/malignancy_associated_with_t_8 L2 - https://ashpublications.org/blood/article-lookup/doi/&lo.doi; DB - PRIME DP - Unbound Medicine ER -