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Antioxidant properties of nitecapone are potentiated by glutathione.
Biochem Mol Biol Int. 1995 Feb; 35(2):387-95.BM

Abstract

The effect of nitecapone (3[(3,4-dihydroxy-5-nitrophenyl) methylene]-2,4-pentanedione) on lipid peroxidation in guinea pig liver microsomes was assessed with the thiobarbituric acid assay. Nitecapone inhibited dose-dependently hydroxyl and peroxyl radical induced lipid peroxidation with IC50-values of 11.1 microM and 16.2 microM, respectively. Nitecapone was an effective antioxidant in native microsomes, where it potentiated glutathione-dependent protection against oxidative stress. Nitecapone provided dose-dependent reduction in lipid peroxidation lasting up to three hours in the presence of glutathione. The long-lasting effect was lost, when the microsomes were boiled. These data suggest that nitecapone is an effective scavenger of oxygen derived free radicals, and that its antioxidant properties are potentiated by glutathione.

Authors+Show Affiliations

Orion-Farmos, Orion Research, Espoo, Finland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7663394

Citation

Nissinen, E, et al. "Antioxidant Properties of Nitecapone Are Potentiated By Glutathione." Biochemistry and Molecular Biology International, vol. 35, no. 2, 1995, pp. 387-95.
Nissinen E, Lindén IB, Pohto P. Antioxidant properties of nitecapone are potentiated by glutathione. Biochem Mol Biol Int. 1995;35(2):387-95.
Nissinen, E., Lindén, I. B., & Pohto, P. (1995). Antioxidant properties of nitecapone are potentiated by glutathione. Biochemistry and Molecular Biology International, 35(2), 387-95.
Nissinen E, Lindén IB, Pohto P. Antioxidant Properties of Nitecapone Are Potentiated By Glutathione. Biochem Mol Biol Int. 1995;35(2):387-95. PubMed PMID: 7663394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant properties of nitecapone are potentiated by glutathione. AU - Nissinen,E, AU - Lindén,I B, AU - Pohto,P, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 387 EP - 95 JF - Biochemistry and molecular biology international JO - Biochem Mol Biol Int VL - 35 IS - 2 N2 - The effect of nitecapone (3[(3,4-dihydroxy-5-nitrophenyl) methylene]-2,4-pentanedione) on lipid peroxidation in guinea pig liver microsomes was assessed with the thiobarbituric acid assay. Nitecapone inhibited dose-dependently hydroxyl and peroxyl radical induced lipid peroxidation with IC50-values of 11.1 microM and 16.2 microM, respectively. Nitecapone was an effective antioxidant in native microsomes, where it potentiated glutathione-dependent protection against oxidative stress. Nitecapone provided dose-dependent reduction in lipid peroxidation lasting up to three hours in the presence of glutathione. The long-lasting effect was lost, when the microsomes were boiled. These data suggest that nitecapone is an effective scavenger of oxygen derived free radicals, and that its antioxidant properties are potentiated by glutathione. SN - 1039-9712 UR - https://www.unboundmedicine.com/medline/citation/7663394/Antioxidant_properties_of_nitecapone_are_potentiated_by_glutathione_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -