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Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products.
Eur Respir J. 1995 Apr; 8(4):593-9.ER

Abstract

Inhaled frusemide protects asthmatic airways against a wide variety of bronchoconstrictor stimuli by unknown mechanisms. To investigate whether inhaled loop diuretics modulate baseline bronchial responsiveness, a randomized, double-blind, placebo-controlled study was conducted to test the ability of frusemide (40 mg) and bumetanide (2 mg) to displace concentration-response curves with methacholine in 14 healthy volunteers. In addition, separate randomized, double-blind studies were carried out to evaluate the effects of oral flurbiprofen, a potent cyclo-oxygenase inhibitor, on the protective action of frusemide against methacholine-induced bronchoconstriction. Inhaled loop diuretics significantly increased the provocative concentration of methacholine causing a 15% decrease in forced expiratory volume in one second (PC15FEV1) from the geometric mean (range) value of 58.6 (9.2-233) mg.ml-1 after placebo administration, to 129 (13.8-505) and to 106 (6.6-510) mg.ml-1 after administration of frusemide and bumetanide, respectively. Similar results were obtained when data from partial flow-volume curves were used for analysis. In the eight subjects studied, pretreatment with oral placebo and inhaled frusemide reduced airway responsiveness to methacholine, with a geometric mean (range) PC15FEV1 value of 116 (25.4-405) mg.ml-1, and premedication with oral flurbiprofen abolished this protective effect, the geometric mean (range) PC15FEV1 methacholine being reduced to a value of 50.3 (16.6-189) mg.ml-1. In addition, oral flurbiprofen alone failed to alter airway responsiveness to methacholine. In view of these findings, it is suggested that bronchoprotective prostaglandins may mediate the effects of loop diuretics against methacholine-induced bronchoconstriction in man.

Authors+Show Affiliations

Istituto Malattie Apparato Respiratorio, Università di Catania, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7664860

Citation

Polosa, R, et al. "Inhaled Loop Diuretics and Basal Airway Responsiveness in Man: Evidence of a Role for Cyclo-oxygenase Products." The European Respiratory Journal, vol. 8, no. 4, 1995, pp. 593-9.
Polosa R, Rajakulasingam K, Prosperini G, et al. Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products. Eur Respir J. 1995;8(4):593-9.
Polosa, R., Rajakulasingam, K., Prosperini, G., Magrì, S., Mastruzzo, C., & Holgate, S. T. (1995). Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products. The European Respiratory Journal, 8(4), 593-9.
Polosa R, et al. Inhaled Loop Diuretics and Basal Airway Responsiveness in Man: Evidence of a Role for Cyclo-oxygenase Products. Eur Respir J. 1995;8(4):593-9. PubMed PMID: 7664860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products. AU - Polosa,R, AU - Rajakulasingam,K, AU - Prosperini,G, AU - Magrì,S, AU - Mastruzzo,C, AU - Holgate,S T, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 593 EP - 9 JF - The European respiratory journal JO - Eur Respir J VL - 8 IS - 4 N2 - Inhaled frusemide protects asthmatic airways against a wide variety of bronchoconstrictor stimuli by unknown mechanisms. To investigate whether inhaled loop diuretics modulate baseline bronchial responsiveness, a randomized, double-blind, placebo-controlled study was conducted to test the ability of frusemide (40 mg) and bumetanide (2 mg) to displace concentration-response curves with methacholine in 14 healthy volunteers. In addition, separate randomized, double-blind studies were carried out to evaluate the effects of oral flurbiprofen, a potent cyclo-oxygenase inhibitor, on the protective action of frusemide against methacholine-induced bronchoconstriction. Inhaled loop diuretics significantly increased the provocative concentration of methacholine causing a 15% decrease in forced expiratory volume in one second (PC15FEV1) from the geometric mean (range) value of 58.6 (9.2-233) mg.ml-1 after placebo administration, to 129 (13.8-505) and to 106 (6.6-510) mg.ml-1 after administration of frusemide and bumetanide, respectively. Similar results were obtained when data from partial flow-volume curves were used for analysis. In the eight subjects studied, pretreatment with oral placebo and inhaled frusemide reduced airway responsiveness to methacholine, with a geometric mean (range) PC15FEV1 value of 116 (25.4-405) mg.ml-1, and premedication with oral flurbiprofen abolished this protective effect, the geometric mean (range) PC15FEV1 methacholine being reduced to a value of 50.3 (16.6-189) mg.ml-1. In addition, oral flurbiprofen alone failed to alter airway responsiveness to methacholine. In view of these findings, it is suggested that bronchoprotective prostaglandins may mediate the effects of loop diuretics against methacholine-induced bronchoconstriction in man. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/7664860/Inhaled_loop_diuretics_and_basal_airway_responsiveness_in_man:_evidence_of_a_role_for_cyclo_oxygenase_products_ DB - PRIME DP - Unbound Medicine ER -