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Effects of sertindole on sleep-wake states, electroencephalogram, behavioral patterns, and epileptic activity of rats.

Abstract

In this study we addressed the effects of the 5-HT2 receptor antagonist sertindole in rats. The compound was administered in doses of 0.08, 0.32, and 1.28 mg/kg, whereas a control group received the solvent. The effects of sertindole on sleep-wake states, behavioral patterns, and background electroencephalogram were studied. Following injection of drug or solvent, we recorded the electroencephalogram and electromyogram for two periods of 4 h in the dark period of the light-dark cycle on 2 successive days. On the 1st day sertindole induced a significant increase in deep slow-wave sleep, but only with a dose of 0.32 mg/kg. Furthermore, a decrease in REM sleep in all three drug groups was established. The suppression of REM sleep was still present on the 2nd day. Sertindole also induced a decrease in alternation between behavioral patterns on the 1st day. There were no significant changes in the spectral content of the background electroencephalogram. In a parallel experiment it appeared that sertindole had no main effects on epileptic spike-wave discharges. This was established with a dose of 1.28 mg/kg sertindole in rats with absence seizures. These findings suggest that sertindole, similar to other compounds modulating 5-HT2 receptors, influences sleep-wake states in rats by decreasing REM sleep and mildly increasing deep slow-wave sleep, whereas behavioral variation is slightly diminished, with no effects on the background EEG and almost no effects on spike-wave discharges.

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  • Authors+Show Affiliations

    ,

    NICI, Department of Psychology, University of Nijmegen, The Netherlands.

    , ,

    Source

    MeSH

    Animals
    Antipsychotic Agents
    Behavior, Animal
    Dose-Response Relationship, Drug
    Electroencephalography
    Electromyography
    Epilepsy, Absence
    Exploratory Behavior
    Imidazoles
    Indoles
    Male
    Rats
    Rats, Inbred Strains
    Rats, Wistar
    Sleep
    Wakefulness

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    7667352

    Citation

    Coenen, A M., et al. "Effects of Sertindole On Sleep-wake States, Electroencephalogram, Behavioral Patterns, and Epileptic Activity of Rats." Pharmacology, Biochemistry, and Behavior, vol. 51, no. 2-3, 1995, pp. 353-7.
    Coenen AM, Ates N, Skarsfeldt T, et al. Effects of sertindole on sleep-wake states, electroencephalogram, behavioral patterns, and epileptic activity of rats. Pharmacol Biochem Behav. 1995;51(2-3):353-7.
    Coenen, A. M., Ates, N., Skarsfeldt, T., & van Luijtelaar, E. L. (1995). Effects of sertindole on sleep-wake states, electroencephalogram, behavioral patterns, and epileptic activity of rats. Pharmacology, Biochemistry, and Behavior, 51(2-3), pp. 353-7.
    Coenen AM, et al. Effects of Sertindole On Sleep-wake States, Electroencephalogram, Behavioral Patterns, and Epileptic Activity of Rats. Pharmacol Biochem Behav. 1995;51(2-3):353-7. PubMed PMID: 7667352.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of sertindole on sleep-wake states, electroencephalogram, behavioral patterns, and epileptic activity of rats. AU - Coenen,A M, AU - Ates,N, AU - Skarsfeldt,T, AU - van Luijtelaar,E L, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 353 EP - 7 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 51 IS - 2-3 N2 - In this study we addressed the effects of the 5-HT2 receptor antagonist sertindole in rats. The compound was administered in doses of 0.08, 0.32, and 1.28 mg/kg, whereas a control group received the solvent. The effects of sertindole on sleep-wake states, behavioral patterns, and background electroencephalogram were studied. Following injection of drug or solvent, we recorded the electroencephalogram and electromyogram for two periods of 4 h in the dark period of the light-dark cycle on 2 successive days. On the 1st day sertindole induced a significant increase in deep slow-wave sleep, but only with a dose of 0.32 mg/kg. Furthermore, a decrease in REM sleep in all three drug groups was established. The suppression of REM sleep was still present on the 2nd day. Sertindole also induced a decrease in alternation between behavioral patterns on the 1st day. There were no significant changes in the spectral content of the background electroencephalogram. In a parallel experiment it appeared that sertindole had no main effects on epileptic spike-wave discharges. This was established with a dose of 1.28 mg/kg sertindole in rats with absence seizures. These findings suggest that sertindole, similar to other compounds modulating 5-HT2 receptors, influences sleep-wake states in rats by decreasing REM sleep and mildly increasing deep slow-wave sleep, whereas behavioral variation is slightly diminished, with no effects on the background EEG and almost no effects on spike-wave discharges. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/7667352/Effects_of_sertindole_on_sleep_wake_states_electroencephalogram_behavioral_patterns_and_epileptic_activity_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(94)00394-X DB - PRIME DP - Unbound Medicine ER -