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Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians.
Ann Neurol 1995; 38(3):463-5AN

Abstract

As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The epsilon 4 allele of APOE was not associated with AD or dementia in this community-based sample. The epsilon 4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the epsilon 4 allele and AD in our previously reported study with African Americans.

Authors+Show Affiliations

Department of Medicine, University of Ibadan, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7668835

Citation

Osuntokun, B O., et al. "Lack of an Association Between Apolipoprotein E Epsilon 4 and Alzheimer's Disease in Elderly Nigerians." Annals of Neurology, vol. 38, no. 3, 1995, pp. 463-5.
Osuntokun BO, Sahota A, Ogunniyi AO, et al. Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians. Ann Neurol. 1995;38(3):463-5.
Osuntokun, B. O., Sahota, A., Ogunniyi, A. O., Gureje, O., Baiyewu, O., Adeyinka, A., ... Unverzagt, F. W. (1995). Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians. Annals of Neurology, 38(3), pp. 463-5.
Osuntokun BO, et al. Lack of an Association Between Apolipoprotein E Epsilon 4 and Alzheimer's Disease in Elderly Nigerians. Ann Neurol. 1995;38(3):463-5. PubMed PMID: 7668835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians. A1 - Osuntokun,B O, AU - Sahota,A, AU - Ogunniyi,A O, AU - Gureje,O, AU - Baiyewu,O, AU - Adeyinka,A, AU - Oluwole,S O, AU - Komolafe,O, AU - Hall,K S, AU - Unverzagt,F W, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 463 EP - 5 JF - Annals of neurology JO - Ann. Neurol. VL - 38 IS - 3 N2 - As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The epsilon 4 allele of APOE was not associated with AD or dementia in this community-based sample. The epsilon 4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the epsilon 4 allele and AD in our previously reported study with African Americans. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/7668835/Lack_of_an_association_between_apolipoprotein_E_epsilon_4_and_Alzheimer's_disease_in_elderly_Nigerians_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1995&volume=38&issue=3&spage=463 DB - PRIME DP - Unbound Medicine ER -