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[Influence of glycemic blood glucose control and incipient diabetic nephropathy on the urinary excretion of N-acetyl-glucosaminidase (NAG) in diabetes mellitus].
An Med Interna 1995; 12(5):216-20AM

Abstract

Plasma glucose, glycated hemoglobin lc (HbAlc), urinary albumin excretion rate (AER) and urinary N-acetyl-glucosaminidase (NAG): creatinine ratio were studied in 100 normotensive diabetic patients with no evidence of overt renal disease and in 45 controls, to find out whether the glycaemic control and incipient nephropathy may influence the urinary excretion of NAG. Twenty-three of the diabetics had microalbuminuria (group II). Group I comprised the 77 diabetics without microalbuminuria. The groups I and II of diabetics were divided into two according to plasma glucose were greater o smaller to 140 mg/dl. The group I of diabetics had greater NAG: creatinine ratio than controls, too (0.41 +/- 0.24 and 0.16 +/- 0.08 mu/mmol creatinine, p < 0.0005); in this group urinary NAG was found to positively correlate with plasma glucose and creatinine (p < 0.0005, r = 0.45). Multiple regression analysis was performed in the whole of diabetics and significant association were identified between urinary NAG excretion and plasma glucose, AER and plasma creatinine (p < 0.0005, r = 0.42). The diabetics with plasma glucose lower to 140 mg/dl had more important correlation NAG: creatinine ratio-AER (p < 0.0001, r = 0.70). It is concluded that measurement of urinary NAG may be of value in the detection of diabetic nephropathy at a potentially reversible stage if the plasma glucose is take into account.

Authors+Show Affiliations

Hospital Universitario Virgen Macarena de Sevilla, Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

7669872

Citation

Sánchez-Hueso, M C., et al. "[Influence of Glycemic Blood Glucose Control and Incipient Diabetic Nephropathy On the Urinary Excretion of N-acetyl-glucosaminidase (NAG) in Diabetes Mellitus]." Anales De Medicina Interna (Madrid, Spain : 1984), vol. 12, no. 5, 1995, pp. 216-20.
Sánchez-Hueso MC, Mateo-Caãs J, Zamora-Madaria E. [Influence of glycemic blood glucose control and incipient diabetic nephropathy on the urinary excretion of N-acetyl-glucosaminidase (NAG) in diabetes mellitus]. An Med Interna. 1995;12(5):216-20.
Sánchez-Hueso, M. C., Mateo-Caãs, J., & Zamora-Madaria, E. (1995). [Influence of glycemic blood glucose control and incipient diabetic nephropathy on the urinary excretion of N-acetyl-glucosaminidase (NAG) in diabetes mellitus]. Anales De Medicina Interna (Madrid, Spain : 1984), 12(5), pp. 216-20.
Sánchez-Hueso MC, Mateo-Caãs J, Zamora-Madaria E. [Influence of Glycemic Blood Glucose Control and Incipient Diabetic Nephropathy On the Urinary Excretion of N-acetyl-glucosaminidase (NAG) in Diabetes Mellitus]. An Med Interna. 1995;12(5):216-20. PubMed PMID: 7669872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of glycemic blood glucose control and incipient diabetic nephropathy on the urinary excretion of N-acetyl-glucosaminidase (NAG) in diabetes mellitus]. AU - Sánchez-Hueso,M C, AU - Mateo-Caãs,J, AU - Zamora-Madaria,E, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 216 EP - 20 JF - Anales de medicina interna (Madrid, Spain : 1984) JO - An Med Interna VL - 12 IS - 5 N2 - Plasma glucose, glycated hemoglobin lc (HbAlc), urinary albumin excretion rate (AER) and urinary N-acetyl-glucosaminidase (NAG): creatinine ratio were studied in 100 normotensive diabetic patients with no evidence of overt renal disease and in 45 controls, to find out whether the glycaemic control and incipient nephropathy may influence the urinary excretion of NAG. Twenty-three of the diabetics had microalbuminuria (group II). Group I comprised the 77 diabetics without microalbuminuria. The groups I and II of diabetics were divided into two according to plasma glucose were greater o smaller to 140 mg/dl. The group I of diabetics had greater NAG: creatinine ratio than controls, too (0.41 +/- 0.24 and 0.16 +/- 0.08 mu/mmol creatinine, p < 0.0005); in this group urinary NAG was found to positively correlate with plasma glucose and creatinine (p < 0.0005, r = 0.45). Multiple regression analysis was performed in the whole of diabetics and significant association were identified between urinary NAG excretion and plasma glucose, AER and plasma creatinine (p < 0.0005, r = 0.42). The diabetics with plasma glucose lower to 140 mg/dl had more important correlation NAG: creatinine ratio-AER (p < 0.0001, r = 0.70). It is concluded that measurement of urinary NAG may be of value in the detection of diabetic nephropathy at a potentially reversible stage if the plasma glucose is take into account. SN - 0212-7199 UR - https://www.unboundmedicine.com/medline/citation/7669872/[Influence_of_glycemic_blood_glucose_control_and_incipient_diabetic_nephropathy_on_the_urinary_excretion_of_N_acetyl_glucosaminidase__NAG__in_diabetes_mellitus]_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -