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The effect of high fructose intake on renal morphology and renal function in rats.
J Physiol Pharmacol. 1995 Jun; 46(2):179-83.JP

Abstract

The aim of this study was to investigate the effect of 2-week fructose feeding on plasma lipids renal function and morphology in the rats. Pair-fed rats were kept individually in metabolic cages for two weeks and given diet containing either 25% fructose or 25% starch (weight/weight). After that time under Nembutal anesthesia blood pressure was measured intra-arterially and blood was withdrawn for cholesterol, triglyceride, insulin, glucose and 24hrs urine was collected to estimate creatinine clearance. At the end of experiment kidneys were removed and fixed for microscopic examination. Creatinine clearance was higher by 15% (p < 0,01) in fructose fed rats and microscopic examination revealed moderate mesangial cells proliferation in animals of the same group. No statistical significant difference was observed with regard to lipids or glucose and insulin between two groups. Our study suggest that fructose feeding is associated with hyperfiltration and hyperplasia of mesangial cells in glomeruli.

Authors+Show Affiliations

Department of Nephrology, University School of Medicine, Gdańsk, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7670126

Citation

Manitius, J, et al. "The Effect of High Fructose Intake On Renal Morphology and Renal Function in Rats." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 46, no. 2, 1995, pp. 179-83.
Manitius J, Baines AD, Roszkiewicz A. The effect of high fructose intake on renal morphology and renal function in rats. J Physiol Pharmacol. 1995;46(2):179-83.
Manitius, J., Baines, A. D., & Roszkiewicz, A. (1995). The effect of high fructose intake on renal morphology and renal function in rats. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 46(2), 179-83.
Manitius J, Baines AD, Roszkiewicz A. The Effect of High Fructose Intake On Renal Morphology and Renal Function in Rats. J Physiol Pharmacol. 1995;46(2):179-83. PubMed PMID: 7670126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of high fructose intake on renal morphology and renal function in rats. AU - Manitius,J, AU - Baines,A D, AU - Roszkiewicz,A, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 179 EP - 83 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 46 IS - 2 N2 - The aim of this study was to investigate the effect of 2-week fructose feeding on plasma lipids renal function and morphology in the rats. Pair-fed rats were kept individually in metabolic cages for two weeks and given diet containing either 25% fructose or 25% starch (weight/weight). After that time under Nembutal anesthesia blood pressure was measured intra-arterially and blood was withdrawn for cholesterol, triglyceride, insulin, glucose and 24hrs urine was collected to estimate creatinine clearance. At the end of experiment kidneys were removed and fixed for microscopic examination. Creatinine clearance was higher by 15% (p < 0,01) in fructose fed rats and microscopic examination revealed moderate mesangial cells proliferation in animals of the same group. No statistical significant difference was observed with regard to lipids or glucose and insulin between two groups. Our study suggest that fructose feeding is associated with hyperfiltration and hyperplasia of mesangial cells in glomeruli. SN - 0867-5910 UR - https://www.unboundmedicine.com/medline/citation/7670126/The_effect_of_high_fructose_intake_on_renal_morphology_and_renal_function_in_rats_ L2 - https://medlineplus.gov/carbohydrates.html DB - PRIME DP - Unbound Medicine ER -