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Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13.
J Intern Med. 1995 Sep; 238(3):249-53.JI

Abstract

Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900-kb region, based on linkage analysis in affected families and deletion mapping of MEN1-associated tumours. In addition, a set of microsatellite markers mapped to the 11q11-13 region were used for linkage analysis in a large Tasmanian MEN1 pedigree, demonstrating the usefulness of these markers for presymptomatic testing in affected families.

Authors+Show Affiliations

Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7673855

Citation

Teh, B T., et al. "Genetic Mapping of the Multiple Endocrine Neoplasia Type 1 Locus at 11q13." Journal of Internal Medicine, vol. 238, no. 3, 1995, pp. 249-53.
Teh BT, Cardinal J, Shepherd J, et al. Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13. J Intern Med. 1995;238(3):249-53.
Teh, B. T., Cardinal, J., Shepherd, J., Hayward, N. K., Weber, G., Cameron, D., & Larsson, C. (1995). Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13. Journal of Internal Medicine, 238(3), 249-53.
Teh BT, et al. Genetic Mapping of the Multiple Endocrine Neoplasia Type 1 Locus at 11q13. J Intern Med. 1995;238(3):249-53. PubMed PMID: 7673855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13. AU - Teh,B T, AU - Cardinal,J, AU - Shepherd,J, AU - Hayward,N K, AU - Weber,G, AU - Cameron,D, AU - Larsson,C, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 249 EP - 53 JF - Journal of internal medicine JO - J Intern Med VL - 238 IS - 3 N2 - Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900-kb region, based on linkage analysis in affected families and deletion mapping of MEN1-associated tumours. In addition, a set of microsatellite markers mapped to the 11q11-13 region were used for linkage analysis in a large Tasmanian MEN1 pedigree, demonstrating the usefulness of these markers for presymptomatic testing in affected families. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/7673855/Genetic_mapping_of_the_multiple_endocrine_neoplasia_type_1_locus_at_11q13_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-6820&date=1995&volume=238&issue=3&spage=249 DB - PRIME DP - Unbound Medicine ER -