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Age-related depletion of linoleic acid desaturation in liver microsomes from young spontaneously hypertensive rats.

Abstract

The present study was designed to investigate the microsomal interconversion of linoleic acid (LA) into arachidonic acid (AA) in young spontaneously hypertensive rats (SHR), in relation to the pathogenesis of hypertension. Our results show lower delta 6 and delta 5 desaturase activities (the limiting steps in the bioconversion of LA into AA) in young SHR, as compared to Wistar Kyoto normotensive rats. This impairment of desaturase activities is raised when the blood pressure increases and is related to the age of animals. The fatty acid composition of liver lipids shows a lower proportion of AA and a higher proportion of LA in SHR than in normotensive rats, confirming the depletion of the enzymatic system studied. Such a loss of desaturase activity may be under the control of hormones involved in the regulation of SHR blood pressure.

Authors+Show Affiliations

Unité de Nutrition Cellulaire et Métabolique, Université de Bourgogne, Faculté des Sciences Mirande, Dijon, France.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7675824

Citation

Narce, M, and J P. Poisson. "Age-related Depletion of Linoleic Acid Desaturation in Liver Microsomes From Young Spontaneously Hypertensive Rats." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 53, no. 1, 1995, pp. 59-63.
Narce M, Poisson JP. Age-related depletion of linoleic acid desaturation in liver microsomes from young spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids. 1995;53(1):59-63.
Narce, M., & Poisson, J. P. (1995). Age-related depletion of linoleic acid desaturation in liver microsomes from young spontaneously hypertensive rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 53(1), 59-63.
Narce M, Poisson JP. Age-related Depletion of Linoleic Acid Desaturation in Liver Microsomes From Young Spontaneously Hypertensive Rats. Prostaglandins Leukot Essent Fatty Acids. 1995;53(1):59-63. PubMed PMID: 7675824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related depletion of linoleic acid desaturation in liver microsomes from young spontaneously hypertensive rats. AU - Narce,M, AU - Poisson,J P, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 59 EP - 63 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 53 IS - 1 N2 - The present study was designed to investigate the microsomal interconversion of linoleic acid (LA) into arachidonic acid (AA) in young spontaneously hypertensive rats (SHR), in relation to the pathogenesis of hypertension. Our results show lower delta 6 and delta 5 desaturase activities (the limiting steps in the bioconversion of LA into AA) in young SHR, as compared to Wistar Kyoto normotensive rats. This impairment of desaturase activities is raised when the blood pressure increases and is related to the age of animals. The fatty acid composition of liver lipids shows a lower proportion of AA and a higher proportion of LA in SHR than in normotensive rats, confirming the depletion of the enzymatic system studied. Such a loss of desaturase activity may be under the control of hormones involved in the regulation of SHR blood pressure. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/7675824/Age_related_depletion_of_linoleic_acid_desaturation_in_liver_microsomes_from_young_spontaneously_hypertensive_rats_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -