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Augmented inflammatory cytokines in primary dengue infection progressing to shock.
Singapore Med J. 1995 Apr; 36(2):218-21.SM

Abstract

Dengue fever (DF) which is caused by four serotypes of dengue virus may in some cases progress into a life threatening situation of dengue haemorrhage fever (DHF) and dengue shock syndrome (DSS). It has been suggested that sequential infection with different dengue virus serotypes predisposes the patient towards DHF/DSS. We report here a primary dengue infection in a 10-year-old boy progressing from DF to DSS while under clinical observation. The report provides unequivocal evidence for the development of DSS in primary dengue infection caused by virus serotype 4. The close relationship between sequential changes in the levels of tumour necrosis factor (TNF), Interleukin 1 and 6 (IL-1 and IL-6) in the serum, to the clinical progression of the disease from DF to DHF/DSS and then to full recovery implicates a pathogenetic role for the inflammatory cytokines. The child also manifested clinical features consistent with Reye's syndrome and this suggests a common pathogenetic origin for DSS and the Reye-like syndrome induced by dengue virus.

Authors+Show Affiliations

University of Malaya, Kuala Lumpur.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7676273

Citation

Iyngkaran, N, et al. "Augmented Inflammatory Cytokines in Primary Dengue Infection Progressing to Shock." Singapore Medical Journal, vol. 36, no. 2, 1995, pp. 218-21.
Iyngkaran N, Yadav M, Sinniah M. Augmented inflammatory cytokines in primary dengue infection progressing to shock. Singapore Med J. 1995;36(2):218-21.
Iyngkaran, N., Yadav, M., & Sinniah, M. (1995). Augmented inflammatory cytokines in primary dengue infection progressing to shock. Singapore Medical Journal, 36(2), 218-21.
Iyngkaran N, Yadav M, Sinniah M. Augmented Inflammatory Cytokines in Primary Dengue Infection Progressing to Shock. Singapore Med J. 1995;36(2):218-21. PubMed PMID: 7676273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Augmented inflammatory cytokines in primary dengue infection progressing to shock. AU - Iyngkaran,N, AU - Yadav,M, AU - Sinniah,M, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 218 EP - 21 JF - Singapore medical journal JO - Singapore Med J VL - 36 IS - 2 N2 - Dengue fever (DF) which is caused by four serotypes of dengue virus may in some cases progress into a life threatening situation of dengue haemorrhage fever (DHF) and dengue shock syndrome (DSS). It has been suggested that sequential infection with different dengue virus serotypes predisposes the patient towards DHF/DSS. We report here a primary dengue infection in a 10-year-old boy progressing from DF to DSS while under clinical observation. The report provides unequivocal evidence for the development of DSS in primary dengue infection caused by virus serotype 4. The close relationship between sequential changes in the levels of tumour necrosis factor (TNF), Interleukin 1 and 6 (IL-1 and IL-6) in the serum, to the clinical progression of the disease from DF to DHF/DSS and then to full recovery implicates a pathogenetic role for the inflammatory cytokines. The child also manifested clinical features consistent with Reye's syndrome and this suggests a common pathogenetic origin for DSS and the Reye-like syndrome induced by dengue virus. SN - 0037-5675 UR - https://www.unboundmedicine.com/medline/citation/7676273/Augmented_inflammatory_cytokines_in_primary_dengue_infection_progressing_to_shock_ L2 - https://medlineplus.gov/dengue.html DB - PRIME DP - Unbound Medicine ER -