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Serology and carriage of Pseudomonas pseudomallei: a prospective study in 1000 hospitalized children in northeast Thailand.
J Infect Dis. 1993 Jan; 167(1):230-3.JI

Abstract

Throat swab cultures and indirect hemagglutination assay (IHA) for Pseudomonas pseudomallei were done in 1000 randomly selected children at a large hospital in northeast Thailand. During 18 months, 17 children with melioidosis were admitted (0.46% of pediatric admissions excluding neonates born in the hospital). Throat swab was positive for P. pseudomallei in 8 of these but in none of 1000 control children. IHA seroprevalence rose at a conversion rate of 24% per year, from 12% in those 1-6 months old to a plateau at approximately 80% after age 4 years. No control child < 4 had an IHA titer > 1:160. The median titer in children with melioidosis was 1:80 (range, negative [in3]-1:5120). Specificity of IHA declined with age, but high titers (> or = 1:640) remained diagnostically useful. Thus, throat carriage of P. pseudomallei indicates active melioidosis. There is no evidence for an asymptomatic carrier state in children. Environmental exposure to P. pseudomallei in endemic areas begins when the child becomes mobile.

Authors+Show Affiliations

Sappasitprasong Hospital, Ubon Ratchatani, Bangkok.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7678106

Citation

Kanaphun, P, et al. "Serology and Carriage of Pseudomonas Pseudomallei: a Prospective Study in 1000 Hospitalized Children in Northeast Thailand." The Journal of Infectious Diseases, vol. 167, no. 1, 1993, pp. 230-3.
Kanaphun P, Thirawattanasuk N, Suputtamongkol Y, et al. Serology and carriage of Pseudomonas pseudomallei: a prospective study in 1000 hospitalized children in northeast Thailand. J Infect Dis. 1993;167(1):230-3.
Kanaphun, P., Thirawattanasuk, N., Suputtamongkol, Y., Naigowit, P., Dance, D. A., Smith, M. D., & White, N. J. (1993). Serology and carriage of Pseudomonas pseudomallei: a prospective study in 1000 hospitalized children in northeast Thailand. The Journal of Infectious Diseases, 167(1), 230-3.
Kanaphun P, et al. Serology and Carriage of Pseudomonas Pseudomallei: a Prospective Study in 1000 Hospitalized Children in Northeast Thailand. J Infect Dis. 1993;167(1):230-3. PubMed PMID: 7678106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serology and carriage of Pseudomonas pseudomallei: a prospective study in 1000 hospitalized children in northeast Thailand. AU - Kanaphun,P, AU - Thirawattanasuk,N, AU - Suputtamongkol,Y, AU - Naigowit,P, AU - Dance,D A, AU - Smith,M D, AU - White,N J, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 230 EP - 3 JF - The Journal of infectious diseases JO - J Infect Dis VL - 167 IS - 1 N2 - Throat swab cultures and indirect hemagglutination assay (IHA) for Pseudomonas pseudomallei were done in 1000 randomly selected children at a large hospital in northeast Thailand. During 18 months, 17 children with melioidosis were admitted (0.46% of pediatric admissions excluding neonates born in the hospital). Throat swab was positive for P. pseudomallei in 8 of these but in none of 1000 control children. IHA seroprevalence rose at a conversion rate of 24% per year, from 12% in those 1-6 months old to a plateau at approximately 80% after age 4 years. No control child < 4 had an IHA titer > 1:160. The median titer in children with melioidosis was 1:80 (range, negative [in3]-1:5120). Specificity of IHA declined with age, but high titers (> or = 1:640) remained diagnostically useful. Thus, throat carriage of P. pseudomallei indicates active melioidosis. There is no evidence for an asymptomatic carrier state in children. Environmental exposure to P. pseudomallei in endemic areas begins when the child becomes mobile. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/7678106/Serology_and_carriage_of_Pseudomonas_pseudomallei:_a_prospective_study_in_1000_hospitalized_children_in_northeast_Thailand_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/167.1.230 DB - PRIME DP - Unbound Medicine ER -