Tags

Type your tag names separated by a space and hit enter

[The effect of molecular structure of hydroxyethyl starch on the elimination kinetics and fluidity of blood in human volunteers].
Arzneimittelforschung. 1993 Feb; 43(2):99-105.A

Abstract

Influence of the Molecular Structure of Hydroxyethyl Starch on Elimination Kinetics and Blood Fluidity in Voluntary Subjects In a cross-over study 6 volunteers received an infusion of 500 ml hydroxyethyl starch of a batch with a high C2/C6-substitution ratio (10.8), or after a washout period of 3 months they received a batch with a low C2/C6-substitution ratio (5.8). The infusion solution was administered at random. The batches were identical as regards their physicochemical characteristics (HES 200/0.5 10%). The concentration and molecular weight distribution of the intravascular hydroxyethyl starch molecules were determined after infusion up to 24 h, the blood fluidity before and after infusion. The substitution ratio of the C2- or C6-atoms in the glucose ring has an effect on the degradation of the hydroxyethyl starch molecule: the molecules with a high C2/C6-substitution ratio appear to be degraded within the same period of time, the resulting degradation products, however, have a higher molecular weight. This influences the blood fluidity. While the haematocrit decrease occurring 1 h after end of infusion is comparable, it keeps up for a longer time in case of a higher C2/C6-substitution ratio. The increase of plasma viscosity is more pronounced in case of a high C2/C6-substitution ratio. Clinical consequences are discussed.

Authors+Show Affiliations

Abteilung für klinische Hämostaseologie und Transfusionsmedizin, Universität des Saarlandes, Homburg/Saar, Osterreich.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

7681289

Citation

Jung, F, et al. "[The Effect of Molecular Structure of Hydroxyethyl Starch On the Elimination Kinetics and Fluidity of Blood in Human Volunteers]." Arzneimittel-Forschung, vol. 43, no. 2, 1993, pp. 99-105.
Jung F, Koscielny J, Mrowietz C, et al. [The effect of molecular structure of hydroxyethyl starch on the elimination kinetics and fluidity of blood in human volunteers]. Arzneimittelforschung. 1993;43(2):99-105.
Jung, F., Koscielny, J., Mrowietz, C., Förster, H., Schimetta, W., Kiesewetter, H., & Wenzel, E. (1993). [The effect of molecular structure of hydroxyethyl starch on the elimination kinetics and fluidity of blood in human volunteers]. Arzneimittel-Forschung, 43(2), 99-105.
Jung F, et al. [The Effect of Molecular Structure of Hydroxyethyl Starch On the Elimination Kinetics and Fluidity of Blood in Human Volunteers]. Arzneimittelforschung. 1993;43(2):99-105. PubMed PMID: 7681289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of molecular structure of hydroxyethyl starch on the elimination kinetics and fluidity of blood in human volunteers]. AU - Jung,F, AU - Koscielny,J, AU - Mrowietz,C, AU - Förster,H, AU - Schimetta,W, AU - Kiesewetter,H, AU - Wenzel,E, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 99 EP - 105 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 43 IS - 2 N2 - Influence of the Molecular Structure of Hydroxyethyl Starch on Elimination Kinetics and Blood Fluidity in Voluntary Subjects In a cross-over study 6 volunteers received an infusion of 500 ml hydroxyethyl starch of a batch with a high C2/C6-substitution ratio (10.8), or after a washout period of 3 months they received a batch with a low C2/C6-substitution ratio (5.8). The infusion solution was administered at random. The batches were identical as regards their physicochemical characteristics (HES 200/0.5 10%). The concentration and molecular weight distribution of the intravascular hydroxyethyl starch molecules were determined after infusion up to 24 h, the blood fluidity before and after infusion. The substitution ratio of the C2- or C6-atoms in the glucose ring has an effect on the degradation of the hydroxyethyl starch molecule: the molecules with a high C2/C6-substitution ratio appear to be degraded within the same period of time, the resulting degradation products, however, have a higher molecular weight. This influences the blood fluidity. While the haematocrit decrease occurring 1 h after end of infusion is comparable, it keeps up for a longer time in case of a higher C2/C6-substitution ratio. The increase of plasma viscosity is more pronounced in case of a high C2/C6-substitution ratio. Clinical consequences are discussed. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/7681289/[The_effect_of_molecular_structure_of_hydroxyethyl_starch_on_the_elimination_kinetics_and_fluidity_of_blood_in_human_volunteers]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:7681289 DB - PRIME DP - Unbound Medicine ER -