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[Acute mixed lineage leukemia showing resistance to AML and ALL therapy].
Rinsho Ketsueki. 1993 May; 34(5):643-8.RK

Abstract

A 51-year-old female was who admitted complaining of cough and slight fever and lower limb petechia. The laboratory examinations revealed leukocytosis (49,400/microliters) with blasts (71%) in the peripheral blood. The NCC was 30 x 10(4)/microliters with 84.8% blasts in the bone marrow. Myeloperoxidase staining was positive for 6% of blasts. Auer rods were not seen in some blasts. Thus, acute myeloblastic leukemia (M1) was diagnosed according to FAB classification. In the peripheral blood, 43.3% of blasts expressed CD19, 10.3% of blasts expressed CD20 and 55.6% of blasts expressed CD33 on admission. Though she received two courses of DCMP according to the DCMP-85 protocol, and one combined course of mitoxantrone, etoposide, and Ara-C. The NCC was 20.0 x 10(4)/microliters with 70% blasts in the bone marrow. CD19 was expressed by 72.4% of blasts and 35.0% expressed CD20. The ALL-90 protocol was started, but remission was not achieved. Thus this case was considered to be acute mixed lineage leukemia.

Authors+Show Affiliations

Kawashima H
Third Department of Internal Medicine, Nihon University School of Medicine.
Iizuka Y
No affiliation info available
Kondou W
No affiliation info available
Hirota H
No affiliation info available
Okuyama Y
No affiliation info available
Kanou M
No affiliation info available
Ichii S
No affiliation info available
Murakami J
No affiliation info available
Tsuchiya T
No affiliation info available
Sawada T
No affiliation info available

MeSH

Antigens, CDAntigens, CD19Antigens, Differentiation, B-LymphocyteAntigens, Differentiation, MyelomonocyticAntineoplastic Combined Chemotherapy ProtocolsB-LymphocytesDrug ResistanceFemaleHumansLeukemia, Myeloid, AcuteMiddle AgedPrecursor Cell Lymphoblastic Leukemia-LymphomaSialic Acid Binding Ig-like Lectin 3

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

7686236

Citation

Kawashima, H, et al. "[Acute Mixed Lineage Leukemia Showing Resistance to AML and ALL Therapy]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 34, no. 5, 1993, pp. 643-8.
Kawashima H, Iizuka Y, Kondou W, et al. [Acute mixed lineage leukemia showing resistance to AML and ALL therapy]. Rinsho Ketsueki. 1993;34(5):643-8.
Kawashima, H., Iizuka, Y., Kondou, W., Hirota, H., Okuyama, Y., Kanou, M., Ichii, S., Murakami, J., Tsuchiya, T., & Sawada, T. (1993). [Acute mixed lineage leukemia showing resistance to AML and ALL therapy]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 34(5), 643-8.
Kawashima H, et al. [Acute Mixed Lineage Leukemia Showing Resistance to AML and ALL Therapy]. Rinsho Ketsueki. 1993;34(5):643-8. PubMed PMID: 7686236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute mixed lineage leukemia showing resistance to AML and ALL therapy]. A1 - Kawashima,H, AU - Iizuka,Y, AU - Kondou,W, AU - Hirota,H, AU - Okuyama,Y, AU - Kanou,M, AU - Ichii,S, AU - Murakami,J, AU - Tsuchiya,T, AU - Sawada,T, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 643 EP - 8 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 34 IS - 5 N2 - A 51-year-old female was who admitted complaining of cough and slight fever and lower limb petechia. The laboratory examinations revealed leukocytosis (49,400/microliters) with blasts (71%) in the peripheral blood. The NCC was 30 x 10(4)/microliters with 84.8% blasts in the bone marrow. Myeloperoxidase staining was positive for 6% of blasts. Auer rods were not seen in some blasts. Thus, acute myeloblastic leukemia (M1) was diagnosed according to FAB classification. In the peripheral blood, 43.3% of blasts expressed CD19, 10.3% of blasts expressed CD20 and 55.6% of blasts expressed CD33 on admission. Though she received two courses of DCMP according to the DCMP-85 protocol, and one combined course of mitoxantrone, etoposide, and Ara-C. The NCC was 20.0 x 10(4)/microliters with 70% blasts in the bone marrow. CD19 was expressed by 72.4% of blasts and 35.0% expressed CD20. The ALL-90 protocol was started, but remission was not achieved. Thus this case was considered to be acute mixed lineage leukemia. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/7686236/[Acute_mixed_lineage_leukemia_showing_resistance_to_AML_and_ALL_therapy]_ DB - PRIME DP - Unbound Medicine ER -