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The distribution of adhesion molecules in human atherosclerosis.

Abstract

Chronic inflammatory cells are a recognized component of atherosclerotic plaques at all stages of development. As adhesion molecules play a fundamental role in inflammatory processes, we have carried out an immunohistochemical investigation of the distribution of endothelial leucocyte adhesion molecule-1 (ELAM-1)*, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in human atherosclerotic lesions. Autopsy specimens from abdominal aorta and coronary arteries were obtained from 21 cases within 24 h of death. ELAM-1 and ICAM-1 were consistently expressed by the entire intimal endothelium of normal coronary arteries and also by the intimal endothelium overlying aortic fatty streaks. Both coronary artery and aortic lesions showed strong staining for ICAM-1 on and around macrophages. VCAM-1 was not detected on intimal endothelial cells, but strong staining of adventitial lymphoid aggregates for this molecule was seen. This work suggests a role for ELAM-1 and ICAM-1 in mononuclear cell recruitment during atherogenesis.

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Authors+Show Affiliations

,

Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Headington, Oxford, UK.

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Source

Histopathology 22:5 1993 May pg 437-44

MeSH

Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
Aorta, Abdominal
Arteriosclerosis
Cell Adhesion Molecules
Coronary Vessels
Endothelium, Vascular
Female
Humans
Immunohistochemistry
Male
Middle Aged
Palatine Tonsil
Phenotype
Staining and Labeling

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7688340

Citation

TY - JOUR T1 - The distribution of adhesion molecules in human atherosclerosis. AU - Wood,K M, AU - Cadogan,M D, AU - Ramshaw,A L, AU - Parums,D V, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 437 EP - 44 JF - Histopathology JO - Histopathology VL - 22 IS - 5 N2 - Chronic inflammatory cells are a recognized component of atherosclerotic plaques at all stages of development. As adhesion molecules play a fundamental role in inflammatory processes, we have carried out an immunohistochemical investigation of the distribution of endothelial leucocyte adhesion molecule-1 (ELAM-1)*, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in human atherosclerotic lesions. Autopsy specimens from abdominal aorta and coronary arteries were obtained from 21 cases within 24 h of death. ELAM-1 and ICAM-1 were consistently expressed by the entire intimal endothelium of normal coronary arteries and also by the intimal endothelium overlying aortic fatty streaks. Both coronary artery and aortic lesions showed strong staining for ICAM-1 on and around macrophages. VCAM-1 was not detected on intimal endothelial cells, but strong staining of adventitial lymphoid aggregates for this molecule was seen. This work suggests a role for ELAM-1 and ICAM-1 in mononuclear cell recruitment during atherogenesis. SN - 0309-0167 UR - https://www.unboundmedicine.com/medline/citation/7688340/The_distribution_of_adhesion_molecules_in_human_atherosclerosis ER -