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Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis.
Cancer Epidemiol Biomarkers Prev. 1993 Jul-Aug; 2(4):329-33.CE

Abstract

Variability in DNA repair capability may be a determinant of interindividual difference in susceptibility to carcinogenic exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides an indirect measure of repair. We report the results of a case-control study of upper aerodigestive tract cancers assessing differences in mutagen sensitivity based on this assay. There were 108 cases with previously untreated squamous cell cancers and 108 age and sex frequency-matched controls selected from blood donors to The University of Texas M. D. Anderson Cancer Center. Sixty-nine% of the cases, compared with 44% of the controls, were classified as mutagen sensitive (breaks per cell > or = 0.8). On multivariate analysis, mutagen sensitivity [odds ratio (OR), 2.5], heavy cigarette smoking (OR, 4.8), and heavy alcohol consumption (OR, 3.1) were associated with significantly increased risk. Stratified analyses showed that the combined effects of cigarette smoking (OR, 8.1) and mutagen sensitivity (OR, 3.2) were suggestive of a multiplicative effect (OR, 23.0). The combined estimate for alcohol use (OR, 3.0) and mutagen sensitivity (OR, 3.0) was 5.8. These data confirm those of a previously published preliminary study of upper aerodigestive cancers and underscore the importance of considering interindividual susceptibility in cancer risk characterization, even for those cancers with well quantified exposures.

Authors+Show Affiliations

Department of Epidemiology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7688625

Citation

Spitz, M R., et al. "Mutagen Sensitivity in Upper Aerodigestive Tract Cancer: a Case-control Analysis." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 2, no. 4, 1993, pp. 329-33.
Spitz MR, Fueger JJ, Halabi S, et al. Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. Cancer Epidemiol Biomarkers Prev. 1993;2(4):329-33.
Spitz, M. R., Fueger, J. J., Halabi, S., Schantz, S. P., Sample, D., & Hsu, T. C. (1993). Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 2(4), 329-33.
Spitz MR, et al. Mutagen Sensitivity in Upper Aerodigestive Tract Cancer: a Case-control Analysis. Cancer Epidemiol Biomarkers Prev. 1993 Jul-Aug;2(4):329-33. PubMed PMID: 7688625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. AU - Spitz,M R, AU - Fueger,J J, AU - Halabi,S, AU - Schantz,S P, AU - Sample,D, AU - Hsu,T C, PY - 1993/7/1/pubmed PY - 1993/7/1/medline PY - 1993/7/1/entrez SP - 329 EP - 33 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 2 IS - 4 N2 - Variability in DNA repair capability may be a determinant of interindividual difference in susceptibility to carcinogenic exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides an indirect measure of repair. We report the results of a case-control study of upper aerodigestive tract cancers assessing differences in mutagen sensitivity based on this assay. There were 108 cases with previously untreated squamous cell cancers and 108 age and sex frequency-matched controls selected from blood donors to The University of Texas M. D. Anderson Cancer Center. Sixty-nine% of the cases, compared with 44% of the controls, were classified as mutagen sensitive (breaks per cell > or = 0.8). On multivariate analysis, mutagen sensitivity [odds ratio (OR), 2.5], heavy cigarette smoking (OR, 4.8), and heavy alcohol consumption (OR, 3.1) were associated with significantly increased risk. Stratified analyses showed that the combined effects of cigarette smoking (OR, 8.1) and mutagen sensitivity (OR, 3.2) were suggestive of a multiplicative effect (OR, 23.0). The combined estimate for alcohol use (OR, 3.0) and mutagen sensitivity (OR, 3.0) was 5.8. These data confirm those of a previously published preliminary study of upper aerodigestive cancers and underscore the importance of considering interindividual susceptibility in cancer risk characterization, even for those cancers with well quantified exposures. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/7688625/Mutagen_sensitivity_in_upper_aerodigestive_tract_cancer:_a_case_control_analysis_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=7688625 DB - PRIME DP - Unbound Medicine ER -