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Rising tumour marker during chemotherapy in a patient with an extra-gonadal germ cell tumour--prolonged survival after tumour excision.
Eur J Surg Oncol. 1993 Aug; 19(4):381-4.EJ

Abstract

A 28-year-old white male presented with a palpable abdominal mass and a grossly elevated beta human chorionic gonadotrophin. He refused investigations to establish the pathology and was treated with cisplatin combination chemotherapy. After an initial fall in his marker, it rose while he was on chemotherapy. The tumour was resected which confirmed the presence of a retroperitoneal germ cell tumour (extra-gonadal). He received further adjuvant chemotherapy and is subsequently clear of disease after being off treatment for more than 5 years. Total resection is not usually considered possible in patients with persistent positive markers after induction chemotherapy. This case shows that surgery should be considered as the results of salvage chemotherapy are poor in these patients.

Authors+Show Affiliations

Department of Radiotherapy, Groote Schuur Hospital, South Africa.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7689489

Citation

Abratt, R P., et al. "Rising Tumour Marker During Chemotherapy in a Patient With an Extra-gonadal Germ Cell Tumour--prolonged Survival After Tumour Excision." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 19, no. 4, 1993, pp. 381-4.
Abratt RP, Ponton AR, Taylor DA. Rising tumour marker during chemotherapy in a patient with an extra-gonadal germ cell tumour--prolonged survival after tumour excision. Eur J Surg Oncol. 1993;19(4):381-4.
Abratt, R. P., Ponton, A. R., & Taylor, D. A. (1993). Rising tumour marker during chemotherapy in a patient with an extra-gonadal germ cell tumour--prolonged survival after tumour excision. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 19(4), 381-4.
Abratt RP, Ponton AR, Taylor DA. Rising Tumour Marker During Chemotherapy in a Patient With an Extra-gonadal Germ Cell Tumour--prolonged Survival After Tumour Excision. Eur J Surg Oncol. 1993;19(4):381-4. PubMed PMID: 7689489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rising tumour marker during chemotherapy in a patient with an extra-gonadal germ cell tumour--prolonged survival after tumour excision. AU - Abratt,R P, AU - Ponton,A R, AU - Taylor,D A, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 381 EP - 4 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 19 IS - 4 N2 - A 28-year-old white male presented with a palpable abdominal mass and a grossly elevated beta human chorionic gonadotrophin. He refused investigations to establish the pathology and was treated with cisplatin combination chemotherapy. After an initial fall in his marker, it rose while he was on chemotherapy. The tumour was resected which confirmed the presence of a retroperitoneal germ cell tumour (extra-gonadal). He received further adjuvant chemotherapy and is subsequently clear of disease after being off treatment for more than 5 years. Total resection is not usually considered possible in patients with persistent positive markers after induction chemotherapy. This case shows that surgery should be considered as the results of salvage chemotherapy are poor in these patients. SN - 0748-7983 UR - https://www.unboundmedicine.com/medline/citation/7689489/Rising_tumour_marker_during_chemotherapy_in_a_patient_with_an_extra_gonadal_germ_cell_tumour__prolonged_survival_after_tumour_excision_ DB - PRIME DP - Unbound Medicine ER -