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Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input.
Neurosci Lett. 1993 May 28; 155(1):29-32.NL

Abstract

In anaesthetized rats the involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the processing of innocuous and noxious sensory inflow from joints was assessed in 27 spinal dorsal horn neurons. Microionophoretic application of either the NMDA antagonists ketamine and D,L-2-amino-5-phosphonovalerate (AP5) or the non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the responses to noxious compression of the knee and ankle joint. By contrast, the responses to innocuous pressure were consistently reduced by CNQX but only exceptionally by NMDA antagonists. Therefore non-NMDA receptors are involved in the processing of innocuous and noxious mechanical stimuli applied to the normal joint whereas NMDA receptors are activated mainly by nociceptive input.

Authors+Show Affiliations

Physiologisches Institut, Universität Würzburg, FRG.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7689717

Citation

Neugebauer, V, et al. "Differential Effects of N-methyl-D-aspartate (NMDA) and non-NMDA Receptor Antagonists On the Responses of Rat Spinal Neurons With Joint Input." Neuroscience Letters, vol. 155, no. 1, 1993, pp. 29-32.
Neugebauer V, Lücke T, Schaible HG. Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input. Neurosci Lett. 1993;155(1):29-32.
Neugebauer, V., Lücke, T., & Schaible, H. G. (1993). Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input. Neuroscience Letters, 155(1), 29-32.
Neugebauer V, Lücke T, Schaible HG. Differential Effects of N-methyl-D-aspartate (NMDA) and non-NMDA Receptor Antagonists On the Responses of Rat Spinal Neurons With Joint Input. Neurosci Lett. 1993 May 28;155(1):29-32. PubMed PMID: 7689717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input. AU - Neugebauer,V, AU - Lücke,T, AU - Schaible,H G, PY - 1993/5/28/pubmed PY - 1993/5/28/medline PY - 1993/5/28/entrez SP - 29 EP - 32 JF - Neuroscience letters JO - Neurosci Lett VL - 155 IS - 1 N2 - In anaesthetized rats the involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the processing of innocuous and noxious sensory inflow from joints was assessed in 27 spinal dorsal horn neurons. Microionophoretic application of either the NMDA antagonists ketamine and D,L-2-amino-5-phosphonovalerate (AP5) or the non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the responses to noxious compression of the knee and ankle joint. By contrast, the responses to innocuous pressure were consistently reduced by CNQX but only exceptionally by NMDA antagonists. Therefore non-NMDA receptors are involved in the processing of innocuous and noxious mechanical stimuli applied to the normal joint whereas NMDA receptors are activated mainly by nociceptive input. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/7689717/Differential_effects_of_N_methyl_D_aspartate__NMDA__and_non_NMDA_receptor_antagonists_on_the_responses_of_rat_spinal_neurons_with_joint_input_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-3940(93)90666-9 DB - PRIME DP - Unbound Medicine ER -