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Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium.
Blood. 1993 Sep 15; 82(6):1891-9.Blood

Abstract

Important complications in sickle cell anemia occur secondary to vascular occlusion, which is postulated to be initiated by interactions of erythrocytes with vascular endothelial cells. In patients with sickle cell anemia, up to 25% of reticulocytes express the alpha 4 beta 1-integrin complex. Furthermore, erythrocytes from patients with sickle cell anemia bind to endothelial cells activated by tumor necrosis factor alpha via (TNF alpha) via interactions between erythrocyte alpha 4 beta 1 and endothelial cell vascular cell adhesion molecule-1 (VCAM-1). Thus, binding of alpha 4 beta 1-expressing reticulocytes to cytokine-activated endothelial cells may initiate vascular complications in sickle cell anemia and perhaps other hemolytic anemias during episodes of infection and inflammation.

Authors+Show Affiliations

Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7691241

Citation

Swerlick, R A., et al. "Alpha 4 Beta 1-integrin Expression On Sickle Reticulocytes: Vascular Cell Adhesion Molecule-1-dependent Binding to Endothelium." Blood, vol. 82, no. 6, 1993, pp. 1891-9.
Swerlick RA, Eckman JR, Kumar A, et al. Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium. Blood. 1993;82(6):1891-9.
Swerlick, R. A., Eckman, J. R., Kumar, A., Jeitler, M., & Wick, T. M. (1993). Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium. Blood, 82(6), 1891-9.
Swerlick RA, et al. Alpha 4 Beta 1-integrin Expression On Sickle Reticulocytes: Vascular Cell Adhesion Molecule-1-dependent Binding to Endothelium. Blood. 1993 Sep 15;82(6):1891-9. PubMed PMID: 7691241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium. AU - Swerlick,R A, AU - Eckman,J R, AU - Kumar,A, AU - Jeitler,M, AU - Wick,T M, PY - 1993/9/15/pubmed PY - 1993/9/15/medline PY - 1993/9/15/entrez SP - 1891 EP - 9 JF - Blood JO - Blood VL - 82 IS - 6 N2 - Important complications in sickle cell anemia occur secondary to vascular occlusion, which is postulated to be initiated by interactions of erythrocytes with vascular endothelial cells. In patients with sickle cell anemia, up to 25% of reticulocytes express the alpha 4 beta 1-integrin complex. Furthermore, erythrocytes from patients with sickle cell anemia bind to endothelial cells activated by tumor necrosis factor alpha via (TNF alpha) via interactions between erythrocyte alpha 4 beta 1 and endothelial cell vascular cell adhesion molecule-1 (VCAM-1). Thus, binding of alpha 4 beta 1-expressing reticulocytes to cytokine-activated endothelial cells may initiate vascular complications in sickle cell anemia and perhaps other hemolytic anemias during episodes of infection and inflammation. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/7691241/Alpha_4_beta_1_integrin_expression_on_sickle_reticulocytes:_vascular_cell_adhesion_molecule_1_dependent_binding_to_endothelium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-4971(20)78366-7 DB - PRIME DP - Unbound Medicine ER -