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Aerosolized acetaldehyde induces histamine-mediated bronchoconstriction in asthmatics.
Am Rev Respir Dis 1993; 148(4 Pt 1):940-3AR

Abstract

It has been reported that acetaldehyde may be a main factor of alcohol-induced bronchoconstriction in Japanese patients with asthma. The purpose of this study was to investigate the direct action of acetaldehyde on the airway in asthmatic and healthy nonasthmatic subjects. We investigated the bronchial response to inhalation of ascending doses (5, 10, 20, and 40 mg/ml) of acetaldehyde in nine asthmatic subjects, who were treated with placebo or terfenadine for 4 days in a double-blind, randomized, placebo-controlled, crossover fashion, and in nine age- and sex-matched healthy subjects. The bronchial responsiveness to inhaled methacholine was also measured in the same asthmatics on a separate day. Inhaled acetaldehyde caused marked (more than 20%) significant decrease in FEV1 in asthmatics after placebo, which was larger than that in asthmatics after terfenadine and in healthy subjects. There was no significant difference in the decrease in FEV1 between asthmatics treated with terfenadine and healthy subjects. There was a significant correlation between the methacholine and acetaldehyde concentrations producing a 20% fall in FEV1 in asthmatics. We conclude that acetaldehyde causes bronchoconstriction indirectly via histamine release in asthmatics, and that nonspecific bronchial hyperresponsiveness is a necessary precondition for the expression of acetaldehyde-produced bronchoconstriction.

Authors+Show Affiliations

Division of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7692778

Citation

Myou, S, et al. "Aerosolized Acetaldehyde Induces Histamine-mediated Bronchoconstriction in Asthmatics." The American Review of Respiratory Disease, vol. 148, no. 4 Pt 1, 1993, pp. 940-3.
Myou S, Fujimura M, Nishi K, et al. Aerosolized acetaldehyde induces histamine-mediated bronchoconstriction in asthmatics. Am Rev Respir Dis. 1993;148(4 Pt 1):940-3.
Myou, S., Fujimura, M., Nishi, K., Ohka, T., & Matsuda, T. (1993). Aerosolized acetaldehyde induces histamine-mediated bronchoconstriction in asthmatics. The American Review of Respiratory Disease, 148(4 Pt 1), pp. 940-3.
Myou S, et al. Aerosolized Acetaldehyde Induces Histamine-mediated Bronchoconstriction in Asthmatics. Am Rev Respir Dis. 1993;148(4 Pt 1):940-3. PubMed PMID: 7692778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aerosolized acetaldehyde induces histamine-mediated bronchoconstriction in asthmatics. AU - Myou,S, AU - Fujimura,M, AU - Nishi,K, AU - Ohka,T, AU - Matsuda,T, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 940 EP - 3 JF - The American review of respiratory disease JO - Am. Rev. Respir. Dis. VL - 148 IS - 4 Pt 1 N2 - It has been reported that acetaldehyde may be a main factor of alcohol-induced bronchoconstriction in Japanese patients with asthma. The purpose of this study was to investigate the direct action of acetaldehyde on the airway in asthmatic and healthy nonasthmatic subjects. We investigated the bronchial response to inhalation of ascending doses (5, 10, 20, and 40 mg/ml) of acetaldehyde in nine asthmatic subjects, who were treated with placebo or terfenadine for 4 days in a double-blind, randomized, placebo-controlled, crossover fashion, and in nine age- and sex-matched healthy subjects. The bronchial responsiveness to inhaled methacholine was also measured in the same asthmatics on a separate day. Inhaled acetaldehyde caused marked (more than 20%) significant decrease in FEV1 in asthmatics after placebo, which was larger than that in asthmatics after terfenadine and in healthy subjects. There was no significant difference in the decrease in FEV1 between asthmatics treated with terfenadine and healthy subjects. There was a significant correlation between the methacholine and acetaldehyde concentrations producing a 20% fall in FEV1 in asthmatics. We conclude that acetaldehyde causes bronchoconstriction indirectly via histamine release in asthmatics, and that nonspecific bronchial hyperresponsiveness is a necessary precondition for the expression of acetaldehyde-produced bronchoconstriction. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/7692778/Aerosolized_acetaldehyde_induces_histamine_mediated_bronchoconstriction_in_asthmatics_ L2 - http://www.atsjournals.org/doi/full/10.1164/ajrccm/148.4_Pt_1.940?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -