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Dimethyl sulfoxide (DMSO) is mutagenic for bacterial mutagenicity tester strains.
Mutat Res. 1993 Nov; 303(3):127-33.MR

Abstract

We used the Ames method with the modification of pre-incubation to evaluate the potential mutagenicity of DMSO. We performed the assays using nine different Ames Salmonella strains and Escherichia coli strains WP2 and WP2uvrA. DMSO was found to be mutagenic for Salmonella typhimurium TA1537 and TA2637 (the latter strain being isogenic to TA1537 but carrying plasmid pKM101) and for E. coli WP2uvrA. The mutagenic activity of DMSO observed at a concentration of 33% was about 10 times higher than the background level (65 revertants induced) for TA1537 after 20 min of incubation, where some lethal toxicity was observed. The mutagenicity of DMSO was observed in the presence and absence of rat liver S9 mix.

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Authors+Show Affiliations

Hakura A
Department of Drug Safety Research, Eisai Co., Ltd., Ibaraki, Japan.
Mochida H
No affiliation info available
Yamatsu K
No affiliation info available

MeSH

AnimalsBiotransformationDimethyl SulfoxideEscherichia coliMutagenicity TestsMutagensRatsSalmonella typhimurium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7694129

Citation

Hakura, A, et al. "Dimethyl Sulfoxide (DMSO) Is Mutagenic for Bacterial Mutagenicity Tester Strains." Mutation Research, vol. 303, no. 3, 1993, pp. 127-33.
Hakura A, Mochida H, Yamatsu K. Dimethyl sulfoxide (DMSO) is mutagenic for bacterial mutagenicity tester strains. Mutat Res. 1993;303(3):127-33.
Hakura, A., Mochida, H., & Yamatsu, K. (1993). Dimethyl sulfoxide (DMSO) is mutagenic for bacterial mutagenicity tester strains. Mutation Research, 303(3), 127-33.
Hakura A, Mochida H, Yamatsu K. Dimethyl Sulfoxide (DMSO) Is Mutagenic for Bacterial Mutagenicity Tester Strains. Mutat Res. 1993;303(3):127-33. PubMed PMID: 7694129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dimethyl sulfoxide (DMSO) is mutagenic for bacterial mutagenicity tester strains. AU - Hakura,A, AU - Mochida,H, AU - Yamatsu,K, PY - 1993/11/1/pubmed PY - 1993/11/1/medline PY - 1993/11/1/entrez SP - 127 EP - 33 JF - Mutation research JO - Mutat Res VL - 303 IS - 3 N2 - We used the Ames method with the modification of pre-incubation to evaluate the potential mutagenicity of DMSO. We performed the assays using nine different Ames Salmonella strains and Escherichia coli strains WP2 and WP2uvrA. DMSO was found to be mutagenic for Salmonella typhimurium TA1537 and TA2637 (the latter strain being isogenic to TA1537 but carrying plasmid pKM101) and for E. coli WP2uvrA. The mutagenic activity of DMSO observed at a concentration of 33% was about 10 times higher than the background level (65 revertants induced) for TA1537 after 20 min of incubation, where some lethal toxicity was observed. The mutagenicity of DMSO was observed in the presence and absence of rat liver S9 mix. SN - 0027-5107 UR - https://www.unboundmedicine.com/medline/citation/7694129/Dimethyl_sulfoxide__DMSO__is_mutagenic_for_bacterial_mutagenicity_tester_strains_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0165-7992(93)90025-Q DB - PRIME DP - Unbound Medicine ER -