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Hepatic blood flow and cardiac output after porta-caval anastomosis in the rat.
Acta Hepatogastroenterol (Stuttg). 1976 Feb; 23(1):31-40.AH

Abstract

Investigations were performed in rats with portacaval anastomosis (PCA) in order to measure hepatic hemodynamics and cardiac output (CO) 3, 6, 14 and 28 days after operation under pentobarbitone anesthesia using the flow fraction distribution method (131I-MAA) of CO. The latter was calculated using Vierordt's principle from blood volume (BV) (125RIHSA-dilution method) and ICG-appearance time (ICG-AT) (ear-densitometry). Even 3 days after PCA CO was increased to 38.7 +/- 5.0 (SD) ml/min/100 g b.w. (normal 23.8), due to an increase of BV from 6.3 +/- 1.4 to 7.5 +/- 0.6 ml/100 g b.w. and a decrease of ICG-AT from 3.6 +/- 0.4 to 2.8 +/- 0.5 s. Arterial hepatic flow fraction of CO increased to 8.7 +/- 2.8% (control: 5.5 +/- 2.4%). Changes could be observed up to day 28. Hepatic blood flow per g liver tended to stabilize but was still decreased at day 28: 1.5 +/- 0.6 ml/min/g liver (control: 2.0 +/- 0.3). The typical hemodynamic changes in human liver cirrhosis can be reproduced by PCA alone. They are considered to be compensatory mechanisms for a reduced portal liver blood flow, which are not found to compensate completely.

Authors

Liehr H
No affiliation info available
Grün M
No affiliation info available
Thiel H
No affiliation info available

MeSH

AnimalsBlood Circulation TimeBlood PressureBlood VolumeEndotoxinsHypertension, PortalLiver CirculationLiver Cirrhosis, ExperimentalMalePortacaval Shunt, SurgicalRadioisotope Dilution TechniqueRatsTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

769471

Citation

Liehr, H, et al. "Hepatic Blood Flow and Cardiac Output After Porta-caval Anastomosis in the Rat." Acta Hepato-gastroenterologica, vol. 23, no. 1, 1976, pp. 31-40.
Liehr H, Grün M, Thiel H. Hepatic blood flow and cardiac output after porta-caval anastomosis in the rat. Acta Hepatogastroenterol (Stuttg). 1976;23(1):31-40.
Liehr, H., Grün, M., & Thiel, H. (1976). Hepatic blood flow and cardiac output after porta-caval anastomosis in the rat. Acta Hepato-gastroenterologica, 23(1), 31-40.
Liehr H, Grün M, Thiel H. Hepatic Blood Flow and Cardiac Output After Porta-caval Anastomosis in the Rat. Acta Hepatogastroenterol (Stuttg). 1976;23(1):31-40. PubMed PMID: 769471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic blood flow and cardiac output after porta-caval anastomosis in the rat. AU - Liehr,H, AU - Grün,M, AU - Thiel,H, PY - 1976/2/1/pubmed PY - 1976/2/1/medline PY - 1976/2/1/entrez SP - 31 EP - 40 JF - Acta hepato-gastroenterologica JO - Acta Hepatogastroenterol (Stuttg) VL - 23 IS - 1 N2 - Investigations were performed in rats with portacaval anastomosis (PCA) in order to measure hepatic hemodynamics and cardiac output (CO) 3, 6, 14 and 28 days after operation under pentobarbitone anesthesia using the flow fraction distribution method (131I-MAA) of CO. The latter was calculated using Vierordt's principle from blood volume (BV) (125RIHSA-dilution method) and ICG-appearance time (ICG-AT) (ear-densitometry). Even 3 days after PCA CO was increased to 38.7 +/- 5.0 (SD) ml/min/100 g b.w. (normal 23.8), due to an increase of BV from 6.3 +/- 1.4 to 7.5 +/- 0.6 ml/100 g b.w. and a decrease of ICG-AT from 3.6 +/- 0.4 to 2.8 +/- 0.5 s. Arterial hepatic flow fraction of CO increased to 8.7 +/- 2.8% (control: 5.5 +/- 2.4%). Changes could be observed up to day 28. Hepatic blood flow per g liver tended to stabilize but was still decreased at day 28: 1.5 +/- 0.6 ml/min/g liver (control: 2.0 +/- 0.3). The typical hemodynamic changes in human liver cirrhosis can be reproduced by PCA alone. They are considered to be compensatory mechanisms for a reduced portal liver blood flow, which are not found to compensate completely. SN - 0300-970X UR - https://www.unboundmedicine.com/medline/citation/769471/Hepatic_blood_flow_and_cardiac_output_after_porta_caval_anastomosis_in_the_rat_ DB - PRIME DP - Unbound Medicine ER -