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Serum cholesterol level and mortality due to suicide and trauma in the Honolulu Heart Program.
Arch Intern Med. 1995 Apr 10; 155(7):695-700.AI

Abstract

BACKGROUND

Recent results from cholesterol level-lowering trials and some, but not all, observational studies support an intriguing link between low or lowered serum cholesterol levels and violent death. The reasons behind this relationship are far from clear.

METHODS

In this report, we further investigate this issue by assessing the relationship of baseline serum cholesterol levels with long-term risk of mortality due to trauma and suicide in a cohort of 7309 middle-aged Japanese-American men.

RESULTS

After 23 years of follow-up, a total of 75 traumatic fatalities and 24 deaths by suicide were documented. Rather than an inverse relation, a positive association between serum cholesterol level and risk of suicide death was observed. After controlling for potential confounders, the relative risk of suicide associated with an increment of 0.98 mmol/L (38 mg/dL) in serum cholesterol level (1 SD) was 1.46 (95% confidence interval, 1.04 to 2.05; P = .02). Multivariate analysis of traumatic mortality failed to detect a relation with serum cholesterol level (relative risk = 0.89; 95% confidence interval, 0.70 to 1.13; P = .44). Heavy alcohol consumption (> 1200 mL of alcohol per month, top quintile) was an independent risk factor for trauma death relative to abstinence (relative risk = 1.86; 95% confidence interval, 1.07 to 3.22; P = .02).

CONCLUSIONS

These findings contradict the hypothesis of an inverse relation between serum cholesterol level and suicide, but they support the hypothesis that heavy alcohol consumption is a risk factor for traumatic fatal events.

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Authors+Show Affiliations

Iribarren C
Department of Preventive Medicine, University of Southern California School of Medicine, Alhambra.
Reed DM
No affiliation info available
Wergowske G
No affiliation info available
Burchfiel CM
No affiliation info available
Dwyer JH
No affiliation info available

MeSH

Analysis of VarianceCholesterolCohort StudiesHawaiiHumansMaleProspective StudiesRisk FactorsSuicideWounds and Injuries

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7695457

Clinical Trial Links

Honolulu Heart Program

Citation

Iribarren, C, et al. "Serum Cholesterol Level and Mortality Due to Suicide and Trauma in the Honolulu Heart Program." Archives of Internal Medicine, vol. 155, no. 7, 1995, pp. 695-700.
Iribarren C, Reed DM, Wergowske G, et al. Serum cholesterol level and mortality due to suicide and trauma in the Honolulu Heart Program. Arch Intern Med. 1995;155(7):695-700.
Iribarren, C., Reed, D. M., Wergowske, G., Burchfiel, C. M., & Dwyer, J. H. (1995). Serum cholesterol level and mortality due to suicide and trauma in the Honolulu Heart Program. Archives of Internal Medicine, 155(7), 695-700.
Iribarren C, et al. Serum Cholesterol Level and Mortality Due to Suicide and Trauma in the Honolulu Heart Program. Arch Intern Med. 1995 Apr 10;155(7):695-700. PubMed PMID: 7695457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cholesterol level and mortality due to suicide and trauma in the Honolulu Heart Program. AU - Iribarren,C, AU - Reed,D M, AU - Wergowske,G, AU - Burchfiel,C M, AU - Dwyer,J H, PY - 1995/4/10/pubmed PY - 1995/4/10/medline PY - 1995/4/10/entrez SP - 695 EP - 700 JF - Archives of internal medicine JO - Arch Intern Med VL - 155 IS - 7 N2 - BACKGROUND: Recent results from cholesterol level-lowering trials and some, but not all, observational studies support an intriguing link between low or lowered serum cholesterol levels and violent death. The reasons behind this relationship are far from clear. METHODS: In this report, we further investigate this issue by assessing the relationship of baseline serum cholesterol levels with long-term risk of mortality due to trauma and suicide in a cohort of 7309 middle-aged Japanese-American men. RESULTS: After 23 years of follow-up, a total of 75 traumatic fatalities and 24 deaths by suicide were documented. Rather than an inverse relation, a positive association between serum cholesterol level and risk of suicide death was observed. After controlling for potential confounders, the relative risk of suicide associated with an increment of 0.98 mmol/L (38 mg/dL) in serum cholesterol level (1 SD) was 1.46 (95% confidence interval, 1.04 to 2.05; P = .02). Multivariate analysis of traumatic mortality failed to detect a relation with serum cholesterol level (relative risk = 0.89; 95% confidence interval, 0.70 to 1.13; P = .44). Heavy alcohol consumption (> 1200 mL of alcohol per month, top quintile) was an independent risk factor for trauma death relative to abstinence (relative risk = 1.86; 95% confidence interval, 1.07 to 3.22; P = .02). CONCLUSIONS: These findings contradict the hypothesis of an inverse relation between serum cholesterol level and suicide, but they support the hypothesis that heavy alcohol consumption is a risk factor for traumatic fatal events. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/7695457/Serum_cholesterol_level_and_mortality_due_to_suicide_and_trauma_in_the_Honolulu_Heart_Program_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/155/pg/695 DB - PRIME DP - Unbound Medicine ER -