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A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.
Oncogene. 1995 Mar 16; 10(6):1229-34.O

Abstract

Most Ewing's sarcomas or related primitive neuroectodermal tumors have the (11;22)(q24;q12) or less frequently the (21;22)(q22;q12) translocation. These rearrangements fuse the EWS gene on chromosome 22q12 to either the FLI1 or ERG genes, both members of the ETS family of transcription factors. Simple variant chromosomal translocations have been occasionally described in these tumors. We have identified a third Ewing's sarcoma translocation, the t(7;22)(p22;q12), that fuses EWS to the human homologue of the murine ETS gene ER81. This gene, designated ETV1 (for ETS Translocation Variant), is located on chromosome band 7p22. Identical EWS nucleotide sequences found in the majority of EWS-FLI1 and EWS-ERG chimeric transcripts are fused to a portion of ETV1 encoding an ETS domain with sequence specific DNA-binding activity. These findings confirm that the fusion of EWS to different ETS family members can result in a similar tumor phenotype.

Authors+Show Affiliations

Department of Experimental Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7700648

Citation

Jeon, I S., et al. "A Variant Ewing's Sarcoma Translocation (7;22) Fuses the EWS Gene to the ETS Gene ETV1." Oncogene, vol. 10, no. 6, 1995, pp. 1229-34.
Jeon IS, Davis JN, Braun BS, et al. A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene. 1995;10(6):1229-34.
Jeon, I. S., Davis, J. N., Braun, B. S., Sublett, J. E., Roussel, M. F., Denny, C. T., & Shapiro, D. N. (1995). A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene, 10(6), 1229-34.
Jeon IS, et al. A Variant Ewing's Sarcoma Translocation (7;22) Fuses the EWS Gene to the ETS Gene ETV1. Oncogene. 1995 Mar 16;10(6):1229-34. PubMed PMID: 7700648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. AU - Jeon,I S, AU - Davis,J N, AU - Braun,B S, AU - Sublett,J E, AU - Roussel,M F, AU - Denny,C T, AU - Shapiro,D N, PY - 1995/3/16/pubmed PY - 1995/3/16/medline PY - 1995/3/16/entrez SP - 1229 EP - 34 JF - Oncogene JO - Oncogene VL - 10 IS - 6 N2 - Most Ewing's sarcomas or related primitive neuroectodermal tumors have the (11;22)(q24;q12) or less frequently the (21;22)(q22;q12) translocation. These rearrangements fuse the EWS gene on chromosome 22q12 to either the FLI1 or ERG genes, both members of the ETS family of transcription factors. Simple variant chromosomal translocations have been occasionally described in these tumors. We have identified a third Ewing's sarcoma translocation, the t(7;22)(p22;q12), that fuses EWS to the human homologue of the murine ETS gene ER81. This gene, designated ETV1 (for ETS Translocation Variant), is located on chromosome band 7p22. Identical EWS nucleotide sequences found in the majority of EWS-FLI1 and EWS-ERG chimeric transcripts are fused to a portion of ETV1 encoding an ETS domain with sequence specific DNA-binding activity. These findings confirm that the fusion of EWS to different ETS family members can result in a similar tumor phenotype. SN - 0950-9232 UR - https://www.unboundmedicine.com/medline/citation/7700648/A_variant_Ewing's_sarcoma_translocation__7 L2 - https://biocyc.org/gene?orgid=HUMAN&id=HS00179 DB - PRIME DP - Unbound Medicine ER -